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European Journal of Cardio-Thoracic Surgery, Vol 10, 48-53, Copyright © 1996 by European Association for Cardio-thoracic Surgery
A Saenz, G Larranaga, L Alvarez, E Greco, A Marrero, M Lunar, C Elosegui, JL Ubago and I Gallo
We performed a randomized study in 101 patients who underwent routine
isolated coronary bypass graft surgery. In 50 cases an entire coated
Carmeda circuit was used (coated group), and an uncoated circuit in the
remaining 51 (uncoated group). A Medtronic Maxima oxygenator and a
Biomedicus Biohead were used in all cases. Patients with coated circuits
received low systemic heparinization with a heparin loading dose of 200
IU/kg, and 300 IU/kg for the control. Activated coagulation time was
maintained at more than 275 s for the coated group versus more than 400 s
for the uncoated one. The mean age of patients was 64.1 +/- 9.6 for coated
and 63.5 +/- 9.7 for the uncoated group. The number of coronary grafts was
3.1 +/- 0.7 for the coated group and 3.1 +/- 0.1 for the uncoated one.
Cross-clamp and bypass times were 53 +/- 14 and 98 +/- 24 min for the
coated, versus 57 +/- 15 and 104 +/- 24 for the uncoated, group. Chest
drainage was 989.4 +/- 509.5 ml for the coated group versus 1435 +/- 1027
for the uncoated one (P < 0.02). The amount of transfused homologous
blood was 723 +/- 597 ml for the coated group versus 1071 +/- 831 ml for
the uncoated one (P < 0.03). Postoperative endotracheal intubation time
was 12.1 +/- 3.6 h for the coated and 14.6 +/- 4.5 h for the uncoated group
(P < 0.05). Bleeding required rethoracotomy in 1/50 of the coated group,
and in 4/51 of the uncoated one. Hospital mortality was 1/50 in the coated,
and 4/51 in the uncoated, group. In our preliminary experience, heparin
coating of an extracorporeal circuit reduces post-operative blood loss and
blood transfusions in routine coronary bypass operations.
ARTICLES
Heparin-coated circuit in coronary surgery. A clinical study
Cardiovascular Unit, Policlinica Guipuzcoa, San Sebastian, Spain.
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 V. Videm, T. E. Mollnes, E. Fosse, B. Mohr, MD, K. Bergh, T.-A. Hagve, A. O. Aasen, and J. L. Svennevig HEPARIN-COATED CARDIOPULMONARY BYPASS EQUIPMENT. I. BIOCOMPATIBILITY MARKERS AND DEVELOPMENT OF COMPLICATIONS IN A HIGH-RISK POPULATION J. Thorac. Cardiovasc. Surg., April 1, 1999; 117(4): 794 - 802. [Abstract] [Full Text] [PDF]
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