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European Journal of Cardio-Thoracic Surgery, Vol 11, 798-800, Copyright © 1997 by European Association for Cardio-thoracic Surgery
RW Landymore, JT Murphy, H Lummis and C Carter
Patients undergoing primary myocardial revascularization were randomized to
one of three drug regimens (low-dose aprotinin, epsilon- aminocaproic Acid
or tranexamic Acid) to determine which drug regimen would most effectively
reduce post-operative bleeding and the need for blood products. All
patients had received 325 mg of aspirin within 48 h before operation. All
three drug regimens reduced the requirements for blood products and
postoperative bleeding after coronary artery bypass operations. There was,
however, no significant difference between drug regimens.
ARTICLES
The use of low-dose aprotinin, epsilon-aminocaproic acid or tranexamic acid for prevention of mediastinal bleeding in patients receiving aspirin before coronary artery bypass operations
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