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Eur J Cardiothorac Surg 1998;13:165-169
© 1998 Elsevier Science NL

Pericardial effusion and AIDS: benefits of surgical drainage

^a Vascular and Thoracic Surgery Department, Assistance Publique Tenon Hospital, 7, rue de la Chine, 75020 Paris, France
^b Infectious Disease Department, Assistance Publique Rothschild Hospital, 33, Boulevard de Picpus, 75012 Paris, France

Received 25 August 1997; received in revised form 1 December 1997; accepted 9 December 1997.

Corresponding author. Tel.: +33 1 40307816; fax: +33 1 40307987.

Objectives: During the last few years, AIDS has been the main cause of large pericardial effusions in urban settings. We have therefore had to perform surgical pericardial drainage for diagnostic and/or therapeutic purposes in AIDS patients. This study was designed to establish the diagnostic and therapeutic yield of pericardial drainage for these patients. Methods: We retrospectively reviewed the data of the 13 AIDS patients with a pericardial effusion, referred to our surgical department between December 1989 and December 1996 for surgical drainage and pericardial biopsy. Results: Cytological studies and searches for bacteria, mycobacteria and parasites were all negative. The histology of the 13 pericardial biopsies disclosed three pericardial locations of a Kaposi’s sarcoma (all three patients had a pre-existent extra-cardiac location of this sarcoma) and one pericardial location of an already known immature mediastinal teratoma. In the nine other cases, the lesions were aspecific. Four patients died of multivisceral failure within 30 days of surgery. For the survivors, surgical drainage afforded relief and there were no clinical signs of recurrent effusion. Conclusions: The cause of pericardial effusion in AIDS is still often unknown, even after pericardial biopsy. Here, aspecific pericarditis was the most common diagnosis. Although the prognosis of such effusion in these patients is known to be poor, surgical drainage provided relief for those who survived the post-operative period.

Key Words: AIDS • Pericardial effusion • Pericarditis • Pericardial drainage • Kaposi’s sarcoma