HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sirin, B. H. Articles by Tetik, C. Search for Related Content PubMed PubMed Citation Articles by Sirin, B. H. Articles by Tetik, C.

Eur J Cardiothorac Surg 1998;14:82-88
© 1998 Elsevier Science NL

Neuroprotective effects of preischemia subcutaneous magnesium sulfate in transient cerebral ischemia¹

Bekir Hayrettin irin^a, Erdal Cokun^b, Levent Ylk^c, Ragp Ortaç^d, Hadiye irin^e, Cihat Tetik^f

^a Department of Cardiovascular Surgery, Pamukkale University Hospital, Denizli, Turkey
^b Department of Neurosurgery, Pamukkale University Hospital, Denizli, Turkey
^c Department of Cardiovascular Surgery, zmir State Hospital, zmir, Turkey
^d Department of Pathology, zmir Behçet Uz Hospital, zmir, Turkey
^e Department of Neurology, Ege University Hospital, zmir, Turkey
^f Department of General Surgery, Pamukkale University Hospital, Denizli, Turkey

Received 14 January 1998; received in revised form 5 April 1998; accepted 7 April 1998.

Corresponding author. Pamukkale Üniversitesi Hastanesi, Doktorlar cad., PK 54, Denizli, Turkey. Tel.: +90 258 2410037; fax: +90 258 2661817.

Objective: Neurological injury due to transient cerebral ischemia is a potential complication of cardiovascular surgery. The neuroprotective effect of magnesium, when given subcutaneously before the ischemia, was assessed in a rat model of transient global cerebral ischemia. Methods: Thirty-six male Wistar albino rats were included to this randomized, controlled, prospective study. In 24 animals, ischemia was induced with four-vessel occlusion technique with the duration of 15 min. MgSO₄ was given 600 mg/kg subcutaneously 48 h before the procedure in group 1 (n=12). Similar volume of saline solution was used in animals of control group (group 2, n=12). The animals in group 3 (sham group, n=12) were anesthetized and subjected to operative dissections without vascular occlusion. Physiological parameters and somatosensory evoked-potentials (SEP) were monitored in animals before ischemia, during ischemia and in the first 30 min of reperfusion. Their neurological outcome had been clinically evaluated and scored up to 4 days postischemia. The intergroup differences were compared. Then the animals were sacrificed and their brains were processed for histopathological examination. Results: In group 3, SEP amplitudes did not change during the procedures, and all animals recovered without neurologic deficits. At the end of ischemic period, the average amplitude was reduced to 5±3% of the baseline in all ischemic animals. This was followed by a gradual return to 87±10% and 83±8% of the initial amplitude after 30 min of reperfusion in group 1 and group 2, respectively (P>0.05). The average neurological score was significantly higher in group 1 than in group 2 at 48, 72 and 96 h after the ischemic insult (P<0.05). Histological observations were clearly correlated with the neurological findings. Conclusion: The results suggest that subcutaneous MgSO₄ reduces cerebral injury and preserves neurologic function when given two days before the transient global ischemia in rats.

Key Words: Magnesium • Cerebral ischemia • Cerebral protection • Somatosensory evoked potentials • Rat

This article has been cited by other articles:

				W. A. Lell, V. G. Nielsen, D. C. McGiffin, F. E. Schmidt Jr, J. K. Kirklin, and A. W. Stanley Jr Glucose-insulin-potassium infusion for myocardial protection during off-pump coronary artery surgery Ann. Thorac. Surg., April 1, 2002; 73(4): 1246 - 1251. [Abstract] [Full Text] [PDF]