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Eur J Cardiothorac Surg 1998;14:527-529
© 1998 Elsevier Science NL

Case report

Cardiopulmonary bypass in sickle cell anaemia without exchange transfusion

National Cardiothoracic Centre, Korle Bu Teaching Hospital, Post Office Box 77, Korle Bu, Accra, Ghana

Received 23 March 1998; received in revised form 22 June 1998; accepted 30 June 1998.

Corresponding author. Tel.: +233 21 780551; fax: +233 21 667196; e-mail: ctu@africaonline.com.gh

To minimize sickling during cardiopulmonary bypass, exchange transfusion is frequently recommended peri-operatively for patients with homozygous sickle cell anaemia to reduce the circulating concentration of HbS. We report the successful management of two children both aged 12 years with sickle cell anaemia (homozygous SS), several sickle cell crises and multiple blood transfusions who underwent cardiopulmonary bypass for mitral valve replacement. No pre- or intra-operative exchange transfusions were employed in the two cases. Furthermore, moderate hypothermia in both cases was not associated with adverse sequelae.

Key Words: Cardiopulmonary bypass • Sickle cell anaemia • Exchange transfusion • Haemoglobinopathy