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Eur J Cardiothorac Surg 1999;15:433-437
© 1999 Elsevier Science NL
a Unit of Thoracic Surgery, University Hospital of Geneva, Geneva, Switzerland
b Division of Anesthesiology, University Hospital of Geneva, Geneva, Switzerland
Received 21 September 1998; received in revised form 21 December 1998; accepted 12 January 1999.
Corresponding author. Department of Surgery, University Hospital of Geneva, rue Micheli-du-Crest 24, 1211 Geneva 14, Switzerland. Tel.: +41-22-372-7873; fax: +41-22-372-7880.
Objective: The goal of the study was to analyze the histological and clinical trends in lung carcinoma and their influence upon the preoperative evaluation, surgical procedures and survival. Methods: We retrospectively reviewed the charts of 1079 consecutive patients who underwent surgery for primary lung carcinoma between 1977 and 1996 in our institution. Patients were divided into five equal 4-year periods according to the year of surgery (19771980; 19811984; 19851988; 19891992; 19931996). Results: Between 19771980 and 19931996, the incidence of squamous cell carcinoma significantly declined, whereas the incidence of adenocarcinoma and bronchioloalveolar carcinoma increased. During the same period, the proportion of squamous cell carcinoma visualized at bronchoscopy and the rate of preoperative histological diagnosis significantly decreased. An increasing proportion of lobectomy and less extended resection was associated with an increasing number of patients with stage I carcinoma. Meanwhile, the operative mortality significantly declined from 9 to 4% and the 5-year survival improved from 25 up to 40%. Conclusion: Over the last two decades, the shift in histological distribution was associated with an increasing proportion of patients with stage I disease, a lower operative mortality and a better 5-year survival.
Key Words: Lung carcinoma Operative mortality Survival Time trend
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