HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Georg Matheis Friedhelm Beyersdorf Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bitu-Moreno, J. Articles by Beyersdorf, F. Search for Related Content PubMed PubMed Citation Articles by Bitu-Moreno, J. Articles by Beyersdorf, F.

Eur J Cardiothorac Surg 1999;15:481-489
© 1999 Elsevier Science NL

Influence of different routes of flush perfusion on the distribution of lung preservation solutions in parenchyma and airways

^a Department of Cardiovascular Surgery, Albert-Ludwigs-University Freiburg, Freiburg, Germany
^b Department of Thoracic and Cardiovascular Surgery, Johann Wolfgang Goethe-University Frankfurt/M., Frankfurt, Germany
^c Faculdade de Medicina de Marilia e Faculdade de Medicina de Botucatu, State University of Sao Paulo, Sao Paulo, Brazil

Received 7 September 1998; received in revised form 6 January 1999; accepted 27 January 1999.

Corresponding author. Tel.: +49-761-270-2818; fax: +49-761-270-2550.

Objective: The present study was performed to investigate the influence of different routes of perfusion on the distribution of the preservation solutions in the lung parenchyma and upper airways. Methods: Pigs were divided into four groups: control (n=6), pulmonary artery (PA) (n=6), simultaneous PA+bronchial artery (BA) (n=8), and retrograde delivery (n=6). After preparation and cannulation, cardioplegia solution and Euro–Collins solution (ECS) for lung preservation were given simultaneously. After removal of the heart, the double lung bloc was harvested. Following parameters were assessed: total and regional perfusion (dye-labeled microspheres), tissue water content, PA, aorta, left atrial and left ventricular pressures, cardiac output and lung temperature. Results: Our data show that flow of the ECS in lung parenchyma did not reach control values (9.4±1.0 ml/min per g lung wet weight) regardless of the route of delivery (PA 6.3±1.5, PA+BA 4.8±0.9, retrograde 2.7±0.9 ml/min per g lung wet weight). However, flow in the proximal and distal trachea were significantly increased by PA+BA delivery (0.970±0.4, respectively, 0.380±0.2 ml/min per g) in comparison with PA (0.023±0.007, respectively, 0.024±0.070 ml/min per g), retrograde (0.009±0.003, respectively, 0.021±0.006 ml/min per g) and control experiments (0.125±0.0018, respectively, 0.105±0.012 ml/g per min). Similarly the highest flow rates in the right main bronchus were achieved by PA+BA delivery (1.04±0.4 ml/min per g) in comparison with 0.11±0.03 in control, 0.033±0.008 in PA, and 0.019±0.005 ml/min per g in retrograde group. Flows in the left main bronchus were 0.09±0.02 ml/min per g in control, 0.045±0.012 ml/min per g in PA, and 0.027±0.006 ml/min per g in retrograde group. The flow rates were significantly (P=0.001) increased by PA+BA delivery of the storage solution (0.97±0.3 ml/min per g). Conclusions: Our data show that the distribution of ECS for lung preservation is significantly improved in airway tissues (trachea and bronchi) if a simultaneous PA+BA delivery is used.

Key Words: Lung transplantation • Lung preservation • Pulmonary+bronchial perfusion

This article has been cited by other articles:

				R. J. Novick Innovative techniques to enhance lung preservation J. Thorac. Cardiovasc. Surg., January 1, 2002; 123(1): 3 - 5. [Full Text] [PDF]

				M. Struber, J. M. Hohlfeld, T. Kofidis, G. Warnecke, J. Niedermeyer, S. P. Sommer, and A. Haverich Surfactant function in lung transplantation after 24 hours of ischemia: Advantage of retrograde flush perfusion for preservation J. Thorac. Cardiovasc. Surg., January 1, 2002; 123(1): 98 - 103. [Abstract] [Full Text] [PDF]