EJCTS Click here to go to Edwards website
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by El-Banayosy, A.
Right arrow Articles by Vigano, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by El-Banayosy, A.
Right arrow Articles by Vigano, M.

Eur J Cardiothorac Surg 1999;15:835-841
© 1999 Elsevier Science NL


The European experience of Novacor left ventricular assist (LVAS) therapy as a bridge to transplant: a retrospective multi-centre study

A. El-Banayosya, M. Dengb, D.Y. Loisancec, H. Vetterd, E. Grondae, M. Loebef, M. Viganog

a Herzzentrum Nordrhein Westfalen, Bad Oeynhausen, Germany
b Westfälische Wilhelms-Universität, Münster, Germany
c Hopital Henri Mondor, Paris, France
d Klinikum Großhadern, Munich, Germany
e Ospedale Niguarda Ca Granda, Milan, Italy
f Deutsches Herzzentrum, Berlin, Germany
g IRCCS Policlinico San Matteo, Pavia, Italy

Received 10 November 1998; received in revised form 3 March 1999; accepted 11 March 1999.

Corresponding author. Herzzentrum NRW, Klinik Fur Thorax und Kardiovaskularchirurgie, Georgstrasse 11, D-32545 Bad Oeynhausen, Germany. Tel.: +49-5731-1353; fax: +49-5731-1343

Objective: Artificial heart devices have suffered from a negative press based on the early Jarvik experience of the 1980s. This is in stark contrast to realities of current left ventricular assist (LVAS) therapy. The Novacor N100 PC wearable left ventricular assist system (LVAS) was introduced in Europe in late 1993. This system allows implanted recipients to be completely autonomous with the system controlled by a small computer and powered by rechargeable batteries. This report represents the initial European experience with the Novacor LVAS. Methods: Since the system was introduced with regulatory approval as a commercial product, clinicians were not bound by the constraints of a study protocol and only minimal data were collected. This report presents the results of a retrospective study of 118 consecutive patients who had the LVAS implanted as a bridge to transplant, in 19 centres over the three year period ending in November 1996. Results: Mortality and morbidity varied widely between centres. The median implant time was 115 days (0–585 days) and 33% of patients returned home, supported by the LVAS. The overall survival on LVAS was 64%. The major causes of death were infection (14%) and MOF (6%). There were no significant device or system failures despite a cumulative patient experience of 24.8 years outside of a hospital environment. Patient selection and management varied greatly between centres and this was reflected in disparate outcomes. Conclusions: Optimal selection and management of LVAS patients has still to be established. While the data available for this report lacked the detail necessary to demonstrate direct causal relationships between selection and management, it was clear from the inter-centre differences that these two factors have a major impact on outcomes. This early experience has directed attention towards improved management regimes. Given the results obtained from the best centres and the ability to discharge patients to lead near-normal lives in the community, the authors believe that the Novacor LVAS now offers a real therapeutic alternative for selected end-stage heart failure patients for whom a donor heart is unavailable or who are unsuitable for transplantation.

Key Words: Left ventricular assist therapy • Bridge to transplant




This article has been cited by other articles:


Home page
HeartHome page
E. B Friedrich and M. Bohm
MANAGEMENT OF END STAGE HEART FAILURE
Heart, May 1, 2007; 93(5): 626 - 631.
[Full Text] [PDF]


Home page
ICVTSHome page
L. Santambrogio, T. Bianchi, M. Fuardo, F. Gazzoli, R. Veronesi, A. Braschi, and M. Maurelli
Right ventricular failure after left ventricular assist device insertion: preoperative risk factors
Interactive CardioVascular and Thoracic Surgery, August 1, 2006; 5(4): 379 - 382.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
M. P. Siegenthaler, J.u. Martin, A. van de Loo, T. Doenst, W. Bothe, and F. Beyersdorf
Implantation of the permanent jarvik-2000 left ventricular assist device: A single-center experience
J. Am. Coll. Cardiol., June 5, 2002; 39(11): 1764 - 1772.
[Abstract] [Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
T. A. Snyder, M. J. Watach, K. N. Litwak, and W. R. Wagner
Platelet activation, aggregation, and life span in calves implanted with axial flow ventricular assist devices
Ann. Thorac. Surg., June 1, 2002; 73(6): 1933 - 1938.
[Abstract] [Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
S. L. Tittle, D. Mandapati, G. S. Kopf, and J. A. Elefteriades
Alternate technique for implantation of left ventricular assist system: left thoracotomy for reoperative cases
Ann. Thorac. Surg., March 1, 2002; 73(3): 994 - 996.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
L. W. Stevenson and R. L. Kormos
Mechanical cardiac support 2000: current applications and future trial design: June 15-16, 2000 Bethesda, Maryland
J. Am. Coll. Cardiol., January 1, 2001; 37(1): 340 - 370.
[Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
P. M. Portner, P. G. M. Jansen, P. E. Oyer, D. R. Wheeldon, and N. Ramasamy
Improved outcomes with an implantable left ventricular assist system: a multicenter study
Ann. Thorac. Surg., January 1, 2001; 71(1): 205 - 209.
[Abstract] [Full Text] [PDF]


Home page
PerfusionHome page
M. Loebe, T. Drews, E. Potapov, D.-V. Ngo, R. zu Dohna, and R. Hetzer
Device selection in mechanical circulatory support
Perfusion, July 1, 2000; 15(4): 313 - 318.
[PDF]


Home page
PerfusionHome page
D R Wheeldon, P G. Jansen, and P M Portner
The Novacor electrical implantable left ventricular assist system
Perfusion, July 1, 2000; 15(4): 355 - 361.
[PDF]


Home page
HeartHome page
S G Williams, D J Wright, and L B Tan
Management of cardiogenic shock complicating acute myocardial infarction: towards evidence based medical practice
Heart, June 1, 2000; 83(6): 621 - 626.
[Full Text]


Home page
Ann. Thorac. Surg.Home page
C. Knosalla, Y.-g. Weng, S. Buz, M. Loebe, and R. Hetzer
Pseudoaneurysm of the outflow graft in a patient with novacor N100 LVAD system
Ann. Thorac. Surg., May 1, 2000; 69(5): 1594 - 1596.
[Abstract] [Full Text] [PDF]


Home page
J. Thorac. Cardiovasc. Surg.Home page
A. El-Banayosy, L. Arusoglu, L. Kizner, G. Tenderich, K. Minami, K. Inoue, and R. Korfer
NOVACOR LEFT VENTRICULAR ASSIST SYSTEM VERSUS HEARTMATE VENTED ELECTRIC LEFT VENTRICULAR ASSIST SYSTEM AS A LONG-TERM MECHANICAL CIRCULATORY SUPPORT DEVICE IN BRIDGING PATIENTS: A PROSPECTIVE STUDY
J. Thorac. Cardiovasc. Surg., March 1, 2000; 119(3): 581 - 587.
[Abstract] [Full Text] [PDF]


Home page
Eur J Heart FailHome page
P. Mohacsi, M. C. Deng, R. Murphy, C.-H. Bergh, E. Gronda, M. Komajda, R. Pacher, J. Spinar, K. Swedberg, and J. F. Cleland
Implantable left ventricular assist systems (LVAS): Recent results. A report from a series of meetings sponsored by the Study Group on Advanced Heart Failure of the Working Group on Heart Failure
Eur J Heart Fail, March 1, 2000; 2(1): 13 - 18.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1999 European Association for Cardio-Thoracic Surgery. Published by Elsevier. All rights reserved.