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Eur J Cardiothorac Surg 1999;15:842-850
© 1999 Elsevier Science NL

Refractory post-transplant airway strictures: successful management with wire stents

^a Department of Thoracic and Cardiovascular Surgery, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL, 60153, USA
^b Division of Pulmonary and Critical Care Medicine, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL, 60153, USA
^c Division of Infectious Diseases, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL, 60153, USA

Received 28 February 1997; received in revised form 21 December 1998; accepted 2 March 1999.

Corresponding author. Present address: Tulane University Medical Center, Department of Surgery, SL22, 1430 Tulane Avenue, New Orleans, LA 70112,USA. Tel.: +1-504-5827998; fax: +1-504-5872141

Objective: Bronchial stenosis, malacia and dehiscence are major airway complications of lung transplantation. Our success in managing this problem evolved from the use of semi-rigid dilators, to balloon dilation and placement of a stent, which were initially silicone, thereafter wire balloon-expandable and finally wire self-expandable. Methods: From May, 1994 until July 1997, we performed a total of 49 single and 58 bilateral lung transplants. Symptoms of shortness of breath, verified by a drop in the forced expiratory volume in one second (FEV₁), led to bronchoscopic inspection of the airway in lung transplant patients. Eighteen patients (16%) suffered a severe form of airway complication (dehiscence or stenosis) in 24 of 151 airways at risk (15.9%). These anastomotic strictures were recalcitrant to conventional therapy. Intervention consisted of rigid bronchoscopy, dilation of the stricture and placement of a stent. Flexible bronchoscopy and fluoroscopy were used for precise placement of the stent. As the initial stent, the Hood silicone stent was placed five times in four patients and the Dumont studded stent five times in four patients. The Palmaz wire stent was used as the initial stent 10 times in seven patients and the Wallstent used eight times in seven patients. Four patients had multiple stents. Balloon inflation moulded the wire stent to the airway. Results: There was no mortality resulting from the airway complication or any intervention. The most serious complication was a perforation of the airway using the semi-rigid dilator that necessitated immediate thoracotomy and re-anastomosis of the bronchus. Other complications necessitated repeat interventions due to restenosis or failure of the stents. The success of the stent placement was measured subjectively by the immediate ease of breathing enjoyed by each patient and objectively by the significant increase of the FEV₁ from a pre-operative mean of 1.19 l (SD 0.64 l) to a post-operative mean of 2.06 l (SD 0.70 l) (P<0001). The mean number of interventions according to the type of wire stent first used was significantly fewer with Wallstent insertion (1.28 (SD 0.48)) than in those patients in whom a Palmaz stent was inserted (5.22 (SD 2.38)) (P<0008). Conclusion: The airway complication of stricture, broncho-malacia or dehiscence following lung transplantation can be managed effectively and easily with the use of balloon catheter dilation followed by precise placement of a self-expandable wire stent. The Wallstent is the superior stent for this application.

Key Words: Lung transplantation • Bronchial stricture • Wire stents • Silicone stents • Balloon dilation • Airway complication

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