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Eur J Cardiothorac Surg 1999;16:533-539
© 1999 Elsevier Science NL

Midterm results after aortic valve replacement with the autologous tissue cardiac valve

^a General Hospital Linz, Linz, Austria
^b Department for Cardiac and Thoracic Surgery, University of Vienna, Austria

Corresponding author. Department of Surgery 1, General Hospital, Krankenhausstrasse 9, A-4020 Linz, Austria. Tel.: +43-732-7806-2136; fax: +43-732-7806-2198

Objective: To assess midterm results after aortic valve replacement (AVR) with an autologous tissue cardiac valve (ATCV). This new technique was developed to construct a tissue prosthesis for AVR using the patients pericardium, harvested at the time of operation with negligible effect on operating time. Methods: Briefly, glutaraldehyde tanned pericardium is mounted on a stent requiring no suturing. Between March 1994 and December 1996, 87 patients, 44/43 M/F and aged 70±6 years had AVR for aortic stenosis (80%), aortic insufficiency (6%) and combined lesions (14%), one patient suffered from endocarditis. Additional coronary artery bypass was done in 25%, aortic root enlargement in 7%. Aortic cross clamp and cardiopulmonary bypass times were 69±21 and 93±29 min. All patients were followed by clinical examination and color flow Doppler echocardiography in 3–12 months interval. Follow up was 99% complete. Results: There were five perioperative deaths (6%), none of them valve related. Eighty-one patients were followed up to a period of 52 months (mean interval 37.5±1.3 months), one patient was lost for follow up. Overall survival was 86, 81, 79 and 71% at 12, 24, 36 and 48 months, respectively. There were 14 late deaths with eight (10%) valve related (four cerebral deaths, four sudden deaths). Sixteen patients (20%) had to be re-operated due to severe valve incompetence. Freedom from reoperation was 98, 97, 90 and 63% at 12, 24, 36, and 48 months, respectively. Valve incompetence occurred suddenly, without previous signs in the follow-up examinations. Selection and preparation of the pericardium, the way of fixation of the tissue – brief immersion in glutaraldehyde – and engineering problems might be responsible for this disastrous outcome. Conclusion: Due to these results we must state, that the ATCV did not fulfill our expectations and presently we can not recommend it as an aortic valve substitute.

Key Words: Autologous pericardium, Cardiac valve, Bioprosthesis, Aortic insufficiency

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