| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Eur J Cardiothorac Surg 1999;16:546-554
© 1999 Elsevier Science NL
a Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, 30623 Hannover, Germany
b Division of Pulmonology, Hannover Medical School, 30623 Hannover, Germany
Corresponding author. Tel.: +49-511-532-6580; fax: +49-511-532-5404
e-mail: harringer{at}thg.mh-hannover.de
Objective: The experience at our institution with various forms of lung transplantation (heart-lung, double lung and single lung) from December 1987 to September 1998 is reviewed and discussed. Methods: During this decade, 282 procedures (46 heart-lungs (HLTx), 142 double lungs (DLTx) and 94 single lungs (SLTx)) have been performed in 258 patients (140 male, 118 female; age: 38±13 years). Major indications included pulmonary fibrosis (n=73), obstructive lung disease (n=55), cystic fibrosis (n=48), primary pulmonary hypertension (n=36), secondary pulmonary hypertension (majority Eisenmenger's syndrome) (n=30), and retransplantation (n=24). Results: Early postoperative mortality (<90 days) was 13.9% (n=36). The 1-, 3-, and 5-year survival rates in all recipients was 77, 70 and 63%, respectively. There was no significant difference in 1-year survival rates between the different procedures (HLTx: 78%, DLTx: 77%, SLTx: 77%). Significantly better 1-year survival was achieved in patients with cystic fibrosis (89%), pulmonary fibrosis (81%), obstructive lung disease (74%), and Eisenmenger's syndrome (83%) when compared to patients with primary pulmonary hypertension (55%). Survival rates remained unchanged during this period despite expanding indications during the last years. Causes of death in 90 recipients (HLTx: n=19, DLTx: n=37, SLTx: n=34) included sepsis (n=42), obliterative bronchiolitis (n=28), cardiac failure (n=5), and early allograft dysfunction (n=2). Freedom from bronchiolitis obliterans syndrome (BOS) (>stage I ISHLT) was 80% at 1 year and 45% at 5 years. Conclusions: Lung transplantation offers a true therapeutic option with good early and midterm results. Yet, chronic graft dysfunction represents a major obstacle for long-term benefit of this procedure.
Key Words: Lung • Transplantation • Survival • Bronchiolitis obliterans syndrome
This article has been cited by other articles:
|
|
 |
|
  B. Skawran, M. Dierich, D. Steinemann, J. Hohlfeld, A. Haverich, B. Schlegelberger, T. Welte, and N. von Neuhoff Bronchial epithelial cells as a new source for differential transcriptome analysis after lung transplantation Eur. J. Cardiothorac. Surg., October 1, 2009; 36(4): 715 - 721. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Bartosik, J. J. Egan, A. Soo, K. F. Remund, L. Nolke, J. F. McCarthy, and A. E. Wood A review of the lung transplantation programme in Ireland 2005-2007 Eur. J. Cardiothorac. Surg., May 1, 2009; 35(5): 807 - 811. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Chang, K. M. Chan, R. J. Lonigro, C. L. Lau, V. N. Lama, K. R. Flaherty, R. Florn, A. Pickens, S. Murray, F. J. Martinez, et al. Surgical patient outcomes after the increased use of bilateral lung transplantation J. Thorac. Cardiovasc. Surg., February 1, 2007; 133(2): 532 - 540. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. George, S. Xydas, V. K. Topkara, C. Ferdinando, E. C. Barnwell, L. Gableman, R. N. Sladen, Y. Naka, and M. C. Oz Clinical Indication for Use and Outcomes After Inhaled Nitric Oxide Therapy Ann. Thorac. Surg., December 1, 2006; 82(6): 2161 - 2169. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Koletsis, A. Chatzimichalis, E. Apostolakis, K. Kokkinis, V. Fotopoulos, M. Melachrinou, M. Chorti, J. Crockett, E. Marinos, I. Bellenis, et al. In Situ Cooling in a Lung Hilar Clamping Model of Ischemia-Reperfusion Injury Experimental Biology and Medicine, September 1, 2006; 231(8): 1410 - 1420. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Strueber, S. Fischer, J. Gottlieb, A. R. Simon, H. Goerler, B. Gohrbandt, T. Welte, and A. Haverich Long-term outcome after pulmonary retransplantation. J. Thorac. Cardiovasc. Surg., August 1, 2006; 132(2): 407 - 412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. de Perrot, C. Chaparro, K. McRae, T. K. Waddell, D. Hadjiliadis, L. G. Singer, A. F. Pierre, M. Hutcheon, and S. Keshavjee Twenty-year experience of lung transplantation at a single center: Influence of recipient diagnosis on long-term survival J. Thorac. Cardiovasc. Surg., May 1, 2004; 127(5): 1493 - 1501. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Pietrantoni, O. A. Minai, N. C. Yu, J. R. Maurer, M. T. Haug III, A. C. Mehta, and A. C. Arroliga Respiratory Failure and Sepsis Are the Major Causes of ICU Admissions and Mortality in Survivors of Lung Transplants Chest, February 1, 2003; 123(2): 504 - 509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. Pierre, Y. Sekine, M. A. Hutcheon, T. K. Waddell, and S. H. Keshavjee Marginal donor lungs: A reassessment J. Thorac. Cardiovasc. Surg., March 1, 2002; 123(3): 421 - 428. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K M Beeh, O Kornmann, J Lill, and R Buhl Induced sputum cell profiles in lung transplant recipients with or without chronic rejection: correlation with lung function Thorax, July 1, 2001; 56(7): 557 - 560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Franke, K. Wiebe, W. Harringer, T. Franke, T. Wittwer, T. Wahlers, and A. Haverich Ten years experience with lung and heart-lung transplantation in primary and secondary pulmonary hypertension Eur. J. Cardiothorac. Surg., October 1, 2000; 18(4): 447 - 452. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
