EJCTS Click here to go to Edwards website
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Tsuguo Naruke
Ryosuke Tsuchiya
Haruhiko Kondo
Haruhiko Nakayama
Hisao Asamura
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Naruke, T.
Right arrow Articles by Asamura, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Naruke, T.
Right arrow Articles by Asamura, H.

Eur J Cardiothorac Surg 1999;16:S17-S24
© 1999 Elsevier Science NL

Lymph node sampling in lung cancer: how should it be done?

Tsuguo Naruke*, Ryosuke Tsuchiya, Haruhiko Kondo, Haruhiko Nakayama, Hisao Asamura

Division of Thoracic Surgery, National Cancer Center Hospital, 1-1, Tsukiji 5-chome, Chuo-ku, Tokyo 104, Japan

* Corresponding author. Tel.: +81-3-5447-2468; fax: +81-3-5447-2468

Objectives: Systematic lymph node dissection in radical operation for lung cancer is recognized as an operative procedure which is expected to improve local control. We investigate the most effective method of lymph node dissection or sampling. Methods: A retrospectrive study was carried out on 1815 patients who underwent systematic lymph node dissection and complete resection. The lymphatic route of metastatis from each lobe was investigated by examining which nodes had the most likelihood of metastasis, or to find out which is the sentinel lymph node in the case of small sized tumor, suitable for the video assisted thoracic surgery (VATS) approach. Results: At N2 level, distribution of major metastases from each lobe are as follows: right upper lobe tumor, 3 – 12.3% (80/648) and/or 4 – 8% (52/648); right middle lobe tumor, 3 and/or 7 – 16.4% (13/79); right lower lobe tumor, 7 – 13.7% (52/380); left upper lobe tumor, 5 – 12.3% (60/489) and/or 6 – 6.7% (33/489); and left lower lobe tumor, 7 – 11.9% (26/219). Small sized tumor requires lymph node sampling upon staging, and the lymph node most likely to become the first metastasis, i.e. sentinel node, are as follows: regardless of the location of tumor, 12, 11, and/or 10 in N1 level, which means dissection or sampling within these locations of lymph nodes are prerequisite. In N2 level, 3 and/or 4 in right upper lobe tumor, 3 and/or 7 in right middle lobe tumor, 7 in right lower lobe tumor, 5 and/or 6 in left upper lobe tumor, and, 7 in left lower lobe tumor. Conclusions: In clinical T1NO lung cancer, sentinel lymph node sampling should be done first, if the nodes are negative, complete mediastinal lymph node dissection might be omitted. On the other hand, if the sentinel nodes are positive for pathology, complete medistinal lymph node dissection is required for curative resection.

Key Words: Lymph node sampling • Sentinel lymph node • Lung cancer • Systematic nodal dissection




This article has been cited by other articles:


Home page
 Eur. J. Cardiothorac. Surg.Home page
S. Sawada, E. Komori, and M. Yamashita
Evaluation of video-assisted thoracoscopic surgery lobectomy requiring emergency conversion to thoracotomy
Eur. J. Cardiothorac. Surg., September 1, 2009; 36(3): 487 - 490.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
A. Watanabe, T. Mishina, S. Ohori, T. Koyanagi, S. Nakashima, T. Mawatari, Y. Kurimoto, and T. Higami
Is video-assisted thoracoscopic surgery a feasible approach for clinical N0 and postoperatively pathological N2 non-small cell lung cancer?
Eur. J. Cardiothorac. Surg., May 1, 2008; 33(5): 812 - 818.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
H. Nomori, K. Ikeda, T. Mori, H. Kobayashi, K. Iwatani, K. Kawanaka, S. Shiraishi, and T. Kobayashi
Sentinel node navigation segmentectomy for clinical stage IA non-small cell lung cancer
J. Thorac. Cardiovasc. Surg., March 1, 2007; 133(3): 780 - 785.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
R. J. Cerfolio, A. S. Bryant, and M. A. Eloubeidi
Routine Mediastinoscopy and Esophageal Ultrasound Fine-Needle Aspiration in Patients With Non-small Cell Lung Cancer Who Are Clinically N2 Negative: A Prospective Study
Chest, December 1, 2006; 130(6): 1791 - 1795.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
D. Lardinois, P. De Leyn, P. Van Schil, R. R. Porta, D. Waller, B. Passlick, M. Zielinski, K. Junker, E. A. Rendina, H.-B. Ris, et al.
ESTS guidelines for intraoperative lymph node staging in non-small cell lung cancer
Eur. J. Cardiothorac. Surg., November 1, 2006; 30(5): 787 - 792.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
D. Lardinois, H. Suter, H. Hakki, V. Rousson, D. Betticher, and H.-B. Ris
Morbidity, Survival, and Site of Recurrence After Mediastinal Lymph-Node Dissection Versus Systematic Sampling After Complete Resection for Non-Small Cell Lung Cancer
Ann. Thorac. Surg., July 1, 2005; 80(1): 268 - 275.
[Abstract] [Full Text] [PDF]

Home page
 MMCTSHome page
F. M.A. Melfi, M. C. Ambrogi, M. Lucchi, and A. Mussi
Video robotic lobectomy
MMCTS, June 28, 2005; 2005(0628): 448.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
H. Nomori, K. Watanabe, T. Ohtsuka, T. Naruke, K. Suemasu, T. Kobayashi, and K. Uno
Fluorine 18-tagged fluorodeoxyglucose positron emission tomographic scanning to predict lymph node metastasis, invasiveness, or both, in clinical T1 N0 M0 lung adenocarcinoma
J. Thorac. Cardiovasc. Surg., September 1, 2004; 128(3): 396 - 401.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
R. Trisolini, L. L. Agli, and M. Patelli
Conventional vs Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration of the Mediastinum
Chest, September 1, 2004; 126(3): 1005 - 1006.
[Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
H. Nomori, T. Ohtsuka, T. Naruke, and K. Suemasu
Histogram analysis of computed tomography numbers of clinical T1 N0 M0 lung adenocarcinoma, with special reference to lymph node metastasis and tumor invasiveness
J. Thorac. Cardiovasc. Surg., November 1, 2003; 126(5): 1584 - 1589.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
K. Sugi, Y. Kaneda, M. Sudoh, H. Sakano, and K. Hamano
Effect of radioisotope sentinel node mapping in patients with cT1 N0 M0 lung cancer
J. Thorac. Cardiovasc. Surg., August 1, 2003; 126(2): 568 - 573.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
H. Nomori, H. Horio, T. Naruke, H. Orikasa, K. Yamazaki, and K. Suemasu
Use of technetium-99m tin colloid for sentinel lymph node identification in non-small cell lung cancer
J. Thorac. Cardiovasc. Surg., September 1, 2002; 124(3): 486 - 492.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
A. P.C. Yim
VATS major pulmonary resection revisited--controversies, techniques, and results
Ann. Thorac. Surg., August 1, 2002; 74(2): 615 - 623.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
B. Passlick, Ch. Born, W. Sienel, and O. Thetter
Incidence of chronic pain after minimal-invasive surgery for spontaneous pneumothorax
Eur. J. Cardiothorac. Surg., March 1, 2001; 19(3): 355 - 359.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
A. P.C. Yim, S. Wan, T. W. Lee, and A. A. Arifi
VATS lobectomy reduces cytokine responses compared with conventional surgery
Ann. Thorac. Surg., July 1, 2000; 70(1): 243 - 247.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1999 European Association for Cardio-Thoracic Surgery. Published by Elsevier. All rights reserved.