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Eur J Cardiothorac Surg 2000;17:8-13
© 2000 Elsevier Science NL

Experimental study on the in vivo behaviour of a new collagen glue in lung surgery

^a Department of Thoracic and Vascular Surgery, Avicenne Hospital, F-93009 Bobigny, France
^b Department of Anatomy and Experimental Surgery, School of Medicine, University of Paris XIII, Martine Midy Foundation, Bobigny, France
^c Department of Pathologic Anatomy, Avicenne Hospital, F-93009 Bobigny, France

Corresponding author. Tel.: +33-1-4895-5231; fax: +33-1-4836-9731
e-mail: anatomie{at}smbh.univ-paris13.fr

Objective: To study the pneumostatic ability of a collagen polymerised with a polysaccharide (GAO^TM) glue in lung surgery; its influence in pleuro-pulmonary adhesion formation; the pulmonary tissue reaction to it, its biodegradability, and the eventual alterations of pulmonary compliance induced by the glue. Methods: Two groups of ten rabbits (controls and treated) were operated under ventilatory assistance by thoracotomy to promote pleural adhesions, and injury to the lung. Repeated chest X-rays were carried out postoperatively. Lungs were examined histologically at day 40. In vitro tests were performed to study glue effects on pulmonary compliance. Results: Air leaks stopped 2 min after glue application. Persistent pneumothorax were likely seen in treated rabbits (ns). Glue induces a temporary reduction of pulmonary compliance. Glue did not increase adhesion formation, or interfere with the healing process. Conclusions: For its properties, GAO seems to be a good and well-tolerated tool to reduce air leaks from the lung, without inducing residual pleural symphysis.

Key Words: Biologic glue • Thoracic surgery • Lung • Experimental study

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