| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Eur J Cardiothorac Surg 2000;17:331-335
© 2000 Elsevier Science NL
a Department of Cardiothoracic Surgery, Westfälische Wilhelms-University Münster, Münster, Germany
b Department of Neurology, Westfälische Wilhelms-University Münster, Münster, Germany
Corresponding author. Klinik und Poliklinik für Thorax-, Herz- & Gefäßchirurgie, Westfälische Wilhelms-Universität, Albert-Schweitzer-Strasse 33, 48149 Münster, Germany. Tel.: +49-251-834-7401; fax: +49-251-834-8316
e-mail: schmid{at}uni-muenster.de
Background: Thromboembolism and bleeding are among the most hazardous complications following implantation of long-term left ventricular support systems. This report focuses on the effect of high dose platelet inhibitor treatment in patients with the Novacor system to prevent thromboembolic events. Methods: Thirty-eight (out of 58) Novacor patients (43±11 years old) were studied in a non-randomized manner. Postimplantation: 20 patients were treated with heparin only (control group), whereas in the other 18 patients aspirin (3x330 mg/day) and dipyridamol (3x75 mg/day) were added to the treatment protocol (aspirin group). Results: Age, body size, underlying heart disease and support interval were comparable among both groups, however, patients in the aspirin group were much sicker with regard to urgency status, postoperative right heart failure and hematologic disorders. Cerebral thromboembolic complications were lower in the aspirin group (33% of patients, 0.4±0.7 events) as compared to the control group (55% (P=0.18), 1.4±2.3 events (P=0.048)). Non-cerebral thromboembolism of surgical relevance was rare. The incidence of bleeding complications was mildly increased in the aspirin group. Conclusion: The addition of high dose platelet inhibitors seems to lower the incidence of thromboembolism in Novacor patients.
Key Words: Ventricular assist system • Aspirin • Stroke
This article has been cited by other articles:
|
|
 |
|
  B. Wei, H. Takayama, and M. D. Bacchetta Pulmonary Lobectomy in a Patient With a Left Ventricular Assist Device. Ann. Thorac. Surg., June 1, 2009; 87(6): 1934 - 1936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Steinlechner, M. Dworschak, B. Birkenberg, M. Duris, P. Zeidler, H. Fischer, L. Milosevic, G. Wieselthaler, E. Wolner, P. Quehenberger, et al. Platelet Dysfunction in Outpatients With Left Ventricular Assist Devices Ann. Thorac. Surg., January 1, 2009; 87(1): 131 - 137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Etz, H. A. Welp, T. D.T. Tjan, A. Hoffmeier, E. Weigang, H. H. Scheld, and C. Schmid Medically Refractory Pulmonary Hypertension: Treatment With Nonpulsatile Left Ventricular Assist Devices Ann. Thorac. Surg., May 1, 2007; 83(5): 1697 - 1705. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Wilhelm, D. Hammel, C. Schmid, A. Rhode, T. Kaan, M. Rothenburger, J. Stypmann, M. Schafers, C. Schmidt, H. A. Baba, et al. Long-term support of 9 patients with the DeBakey VAD for more than 200 days J. Thorac. Cardiovasc. Surg., October 1, 2005; 130(4): 1122 - 1129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Nabavi, J. Stockmann, C. Schmid, M. Schneider, D. Hammel, H. H. Scheld, and E. B. Ringelstein Doppler microembolic load predicts risk of thromboembolic complications in Novacor patients J. Thorac. Cardiovasc. Surg., July 1, 2003; 126(1): 160 - 167. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
