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Eur J Cardiothorac Surg 2000;18:98-103
© 2000 Elsevier Science NL

Circulating soluble gp130, soluble IL-6R, and IL-6 in patients undergoing cardiac surgery, with or without extracorporeal circulation

^a Cardio-thoracic Surgery Unit, Poitiers Hospital, Poitiers, France
^b Cytokine group, ESA CNRS 6031, IBMIG, Université de Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers Cedex, France
^c UMR CNRS 6558, Université de Poitiers, Poitiers, France
^d DIACLONE Laboratory, Besançon, France

Received 7 October 1999; received in revised form 4 February 2000; accepted 9 February 2000.

Corresponding author. Tel.: +33-5-4945-4057; fax: +33-5-4945-3503
e-mail: jean-claude.lecron{at}campus.univ-poitiers.fr

Objective: Soluble forms of interleukin-6 (IL-6) receptors are known to modulate biological activities of IL-6. The purpose of the study was to measure circulating levels of IL-6, sIL-6R and sgp130 in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass (CPB group) or without CPB (non-CPB group). Methods: The CPB group included 19 patients and the non-CPB group 12 patients. Sera levels of IL-6, sIL-6R and sgp130 were measured by specific ELISA at the beginning of the operation (T0, 15 min before skin incision) and 6 h later (T1). Results: IL-6 sera levels were respectively 9±20 pg/ml (mean±SD) and 13±19 pg/ml at T0 and reached 340±250 pg/ml and 965±1060 pg/ml at T1 in CPB and non-CPB groups, indicating a significant increase from T0 to T1, but no differences between the two groups. When compared to T0 values, sgp130 levels decreased in both groups (respectively 105±37 and 115±35 ng/ml at T0 for CPB and non-CPB groups, and 72±25 and 84±29 ng/ml at T1) while we are not able to detect differences between the groups. Whatever the group or the time, sIL-6R concentrations remained unchanged. Conclusions: We showed that the increase of IL-6 after artery bypass grafting was similar between patients operated with CPB or without CPB. We conclude that the main inductor of IL-6 release is linked to surgical trauma rather than a reaction to CPB. Since it is known that gp130 inhibits IL-6-biological activities, we suggest that the decrease of sgp130 sera levels could further enhance the inflammatory effects of IL-6 in cardiac surgery.

Key Words: Interleukin-6 • sIL-6R • sgp130 • Cardiopulmonary bypass • Cardiac surgery

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