| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Eur J Cardiothorac Surg 2001;19:482-486
© 2001 Elsevier Science NL
a University Laboratory of Physiology, University of Oxford, Parks Road, Oxford, OX1 3PT, UK
b Oxford Heart Centre, John Radcliffe Hospital, Oxford, OX3 9DU, UK
Received 4 November 2000; received in revised form 18 January 2001; accepted 21 January 2001.
Corresponding author. Tel.: +44-1865-221121; fax: +44-1865-221956
e-mail: david.taggart{at}orh.anglox.nhs.uk
Objectives: There is an increasing use of arterial conduits for coronary artery bypass grafting, and the radial artery is commonly used as the third graft. The major drawback of the radial artery is its proclivity to spasm. Both papaverine and phenoxybenzamine have been recommended as topical vasodilators in clinical practice. We compared the efficacy of both drugs to prevent radial artery spasm and their ability to preserve endothelial function. Methods: The ability of both drugs to prevent alpha-adrenoreceptor mediated constriction was tested in vitro in an organ bath in radial artery segments obtained from 20 patients. Vessel viability was determined by potassium (K+) constriction, and endothelial function was assessed by observing endothelium-dependent relaxation by a synthetic analogue of acetylcholine, carbachol. Results: Papaverine consistently abolished and prevented spasm for up to a maximum of 30 min in all segments. In contrast, phenoxybenzamine consistently abolished and prevented radial artery spasm in all segments for at least 6 h. Whereas papaverine damaged the endothelium of 70% of vessels, there was no evidence of endothelial damage in any arterial segments after exposure to phenoxybenzamine. Conclusions: Phenoxybenzamine more effectively prevents alpha-adrenoreceptor mediated spasm of the human radial artery than papaverine. It is also less harmful to the endothelium.
Key Words: Radial • Vasospasm • Phenoxybenzamine • Papaverine
This article has been cited by other articles:
|
|
 |
|
  S. Attaran, L. John, and A. El-Gamel Clinical and Potential Use of Pharmacological Agents to Reduce Radial Artery Spasm in Coronary Artery Surgery Ann. Thorac. Surg., April 1, 2008; 85(4): 1483 - 1489. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Mueed, T. Tazzeo, C. Liu, E. Pertens, Y. Zhang, I. Cybulski, L. Semelhago, J. Noora, A. Lamy, K. Teoh, et al. Isoprostanes constrict human radial artery by stimulation of thromboxane receptors, Ca2+ release, and RhoA activation J. Thorac. Cardiovasc. Surg., January 1, 2008; 135(1): 131 - 138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kulik, F. D. Rubens, D. Gunning, M. E. Bourke, T. G. Mesana, and M. Ruel Radial Artery Graft Treatment With Phenoxybenzamine is Clinically Safe and May Reduce Perioperative Myocardial Injury Ann. Thorac. Surg., February 1, 2007; 83(2): 502 - 509. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Tarhan, T. Kehlibar, F. Yapici, M. Yilmaz, Y. Arslan, N. Yapici, and A. Ozler Role of physiological state 'normothermia' in internal thoracic artery spasm after harvesting Eur. J. Cardiothorac. Surg., November 1, 2006; 30(5): 749 - 752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Formica, O. Ferro, M. Brustia, F. Corti, L. Colagrande, E. Bosisio, and G. Paolini Effects of Papaverine and Glycerilnitrate-Verapamil Solution as Topical and Intraluminal Vasodilators for Internal Thoracic Artery Ann. Thorac. Surg., January 1, 2006; 81(1): 120 - 124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Teskin, B. S. Uydes-Dogan, Y. Enc, F. I. Alp, D. Kaleli, S. Keser, T. Iyigun, F. Bilgen, S. Dagsali, and O. Ozdemir Comparative Effects of Tolazoline and Nitroprusside on Human Isolated Radial Artery Ann. Thorac. Surg., January 1, 2006; 81(1): 125 - 131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Kerendi, M. E. Halkos, J. S. Corvera, H. Kin, Z.-Q. Zhao, M. Mosunjac, R. A. Guyton, and J. Vinten-Johansen Inhibition of myosin light chain kinase provides prolonged attenuation of radial artery vasospasm Eur. J. Cardiothorac. Surg., December 1, 2004; 26(6): 1149 - 1155. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mussa, T. Prior, N. Alp, K. Wood, K. M. Channon, and D. P. Taggart Duration of action of antispasmodic agents: novel use of a mouse model as an in vivo pharmacological assay Eur. J. Cardiothorac. Surg., November 1, 2004; 26(5): 988 - 994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. F. Chong, P. J. L. Ong, N. Moat, and P. Collins Effects of hydrostatic distention on in vitro vasoreactivity of radial artery conduits J. Thorac. Cardiovasc. Surg., October 1, 2004; 128(4): 609 - 614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mayranpaa, J. Simpanen, M. W. Hess, K. Werkkala, and P. T. Kovanen Arterial endothelial denudation by intraluminal use of papaverine-NaCl solution in coronary bypass surgery Eur. J. Cardiothorac. Surg., April 1, 2004; 25(4): 560 - 566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Abu-Omar, S. Mussa, K. Anastasiadis, S. Steel, L. Hands, and D. P. Taggart Duplex ultrasonography predicts safety of radial artery harvest in the presence of an abnormal Allen test Ann. Thorac. Surg., January 1, 2004; 77(1): 116 - 119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mussa, T. J. Guzik, E. Black, M. A. Dipp, K. M. Channon, and D. P. Taggart Comparative efficacies and durations of action of phenoxybenzamine, verapamil/nitroglycerin solution, and papaverine as topical antispasmodics for radial artery coronary bypass grafting J. Thorac. Cardiovasc. Surg., December 1, 2003; 126(6): 1798 - 1805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Corvera, C. D. Morris, J. M. Budde, D. A. Velez, J. D. Puskas, O. M. Lattouf, W. A. Cooper, R. A. Guyton, and J. Vinten-Johansen Pretreatment with phenoxybenzamine attenuates the radial artery's vasoconstrictor response to {alpha}-adrenergic stimuli J. Thorac. Cardiovasc. Surg., November 1, 2003; 126(5): 1549 - 1554. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Conant, M. J. Shackcloth, A. Y. Oo, M. R. Chester, A. W. M. Simpson, and W. C. Dihmis Phenoxybenzamine treatment is insufficient to prevent spasm in the radial artery: the effect of other vasodilators J. Thorac. Cardiovasc. Surg., August 1, 2003; 126(2): 448 - 454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Modine, S. Al-Ruzzeh, W. Mazrani, F. Azeem, M. Bustami, C. Ilsley, and M. Amrani Use of radial artery graft reduces the morbidity of coronary artery bypass graft surgery in patients aged 65 years and older Ann. Thorac. Surg., October 1, 2002; 74(4): 1144 - 1147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Taggart Reply Ann. Thorac. Surg., April 1, 2002; 73(4): 1359 - 1360. [Full Text] [PDF]
|
|
|
|
|
|
S. Al-Ruzzeh, S. George, M. Bustami, K. Nakamura, S. Khan, M. Yacoub, and M. Amrani The early clinical and angiographic outcome of sequential coronary artery bypass grafting with the off-pump technique J. Thorac. Cardiovasc. Surg., March 1, 2002; 123(3): 525 - 530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Velez, C. D. Morris, S. Muraki, J. M. Budde, R. N. Otto, Z.-Q. Zhao, R. A. Guyton, and J. Vinten-Johansen Brief pretreatment of radial artery conduits with phenoxybenzamine prevents vasoconstriction long term Ann. Thorac. Surg., December 1, 2001; 72(6): 1977 - 1984. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
