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Eur J Cardiothorac Surg 2001;19:653-656
© 2001 Elsevier Science NL

Quantitative measurement of endothelium derived nitric oxide production of the internal mammary artery bypass graft during extracorporeal circulation

^a Department of Cardiovascular Surgery, Faculty of Health Sciences, Semmelweis University, 1135 Budapest, Szabolcs u, 35, Hungary
^b Research Laboratory, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary

Received 20 July 2000; received in revised form 26 January 2001; accepted 14 February 2001.

Corresponding author. Tel.: +361-350-4736; fax: +361-350-4777
e-mail: drtarrferenc{at}hotmail.com

Objective: This study was undertaken to determine the extent of endothelium derived nitric oxide (EDNO) production of the internal mammary artery (IMA) bypass graft and of the native coronary circulation by measuring its stable metabolite (NO2: nitrite) in different sampling sites: internal mammary free cut end flow, in the coronary sinus prior and after anastomosis completion, and to compare them to the nitrite level of the normal plasma. Methods: Nitrite level was determined with fluoroscopy using 4 hydroxycoumarin nitrozation in 50 consecutive patient undergoing onpump myocardial revascularization. Results: Nitrite levels in the normal plasma were found to be 31.2 µmol. Nitrite level in systemic and coronary circulation after total heparinization, prior to extracorporeal circulation (ECC) was found to be 60.8 µmol (lower quartile /l.q./: 46.6 µmol, upper quartile /u.q./: 70.0 µmol,) and 58.3 µmol,(l.q.:47.8 µmol, u.q.:70.0 µmol) respectively, and of the IMA bypass graft free cut end flow was 54.4 µmol,(l.q.:42.0 µmol, u.q.:66.8 µmol) while in the coronary sinus, after completion the IMA anastomosis, it was 45.71 µmol (l.q.: 35.0 µmol, u.q.: 55.0 µmol), (all geometric mean). Conclusions: Total heparinization enhances EDNO production. Nitrite concentration in the IMA free cut end flow is similar or greater, than that of the native coronary circulation, however, after IMA bypass graft construction significant reduction (P<0.001) could be measured in the coronary sinus.

Key Words: Endothelium derived nitric oxide • Myocardial revascularization • Internal mammary artery

This article has been cited by other articles:

				F. I. Tarr, M. Sasvari, M. Tarr, and R. Racz Evidence of Nitric Oxide Produced by the Internal Mammary Artery Graft in Venous Drainage of the Recipient Coronary Artery Ann. Thorac. Surg., November 1, 2005; 80(5): 1728 - 1731. [Abstract] [Full Text] [PDF]