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Eur J Cardiothorac Surg 2001;20:883-885
© 2001 Elsevier Science NL

Case report

Ischemic heart disease associated with protein C deficiency

^a Department of Cardiovascular Surgery, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo 105-8470, Japan
^b Department of Cardiothoracic Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan

Received 1 May 2001; received in revised form 27 June 2001; accepted 10 July 2001.

Corresponding author. Tel./fax: +81-3-3947-3210
e-mail: mikio-ninomiya{at}par.odn.ne.jp

Three patients of ischemic heart disease associated with protein C deficiency are reported. Although delayed diagnosis of protein C deficiency resulted in the failure of repeated interventions, coronary artery bypass grafting performed after making the correct diagnosis has led to satisfactory mid-term results under strict anticoagulation therapy. The level of protein C should be measured more frequently in the field of ischemic heart disease and earlier diagnosis of its deficiency should be made, because measurement of protein C does not cost much.

Key Words: Protein C deficiency • Ischemic heart disease • Coronary artery bypass grafting

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