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Eur J Cardiothorac Surg 2002;21:307-313
© 2002 Elsevier Science NL
a Department of General Surgery and Digestive Apparatus I, Virgen de la Arrixaca University Hospital, 30120, El Palmar, Murcia, Spain
b Department of Thoracic Surgery, Virgen de la Arrixaca University Hospital, 30120, El Palmar, Murcia, Spain
c Department of Pathological Anatomy, Virgen de la Arrixaca University Hospital, 30120, El Palmar, Murcia, Spain
Received 5 July 2001; received in revised form 16 October 2001; accepted 7 November 2001.
* Corresponding author. Av/. Libertad no. 208, CP 30. 007, Casillas, Murcia, Spain. Tel.: +34-968-23-07-48; fax: +34-968-36-97-16
e-mail: arzrios{at}teleline.es
Objectives: The primary thymic epithelial neoplasms (PTENs) are uncommon tumours with a broad spectrum of both biological and morphological features. The aim of this study is to analyse the prognostic factors that influence survival. Methods: Forty-four patients with a complete follow-up were analysed. Nine patients (20.5%) were asymptomatic, the most common symptoms in the rest being myasthenia gravis and dyspnoea. All the patients underwent surgery, 30 cases (68.2%) receiving total thymectomy and the rest a partial resection or biopsy. Marino–Müller's histological classification showed the mixed type to be the most common (52.3%). Clinical staging was done according to the Masaoka classification, which gave the most common stage as stage III (34.1%). Results: Twelve patients died during a mean follow-up of 8.2±3.5 years. The accumulated survival rate was 77% at 5 years and 60% at 10 years. Analysis of the survival curves shows significant differences (P<0.05) when considering surgical technique, clinical staging and histological subtype. The multivariate analysis shows the only parameters with prognostic significance in PTENs to be clinical staging and histological type (P<0.001). Conclusions: The most important prognostic factors in PTENs are Masaoka's clinical staging and Marino–Müller's histological subtype.
Key Words: Thymic epithelial neoplasms • Thymoma • Epidermoid carcinoma • Lympho-epithelial carcinoma • Surgery • Radiotherapy
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