HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Xavier M. Mueller Judith Horisberger Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mueller, X. M. Articles by von Segesser, L. K. Search for Related Content PubMed PubMed Citation Articles by Mueller, X. M. Articles by von Segesser, L. K. Related Collections Extracorporeal circulation

Eur J Cardiothorac Surg 2002;21:840-846
© 2002 Elsevier Science NL

A new concept of integrated cardiopulmonary bypass circuit

Department of Cardio-vascular Surgery, Centre Hospitalier Universitaire Vaudois (CHUV), Rue du Bugnon 46, CH-1011 Lausanne, Switzerland

Received 12 September 2001; received in revised form 23 December 2001; accepted 30 January 2002.

* Corresponding author. Tel.: +41-21-314-2280; fax: +41-21-314-2278
e-mail: xavier.mueller{at}chuv.hospvd.ch

Objective: Standard cardiopulmonary bypass (CPB) circuits with their large surface area and volume contribute to postoperative systemic inflammatory reaction and hemodilution. In order to minimize these problems a new approach has been developed resulting in a single disposable, compact arterio-venous loop, which has integral kinetic-assist pumping, oxygenating, air removal, and gross filtration capabilities (CardioVention Inc., Santa Clara, CA, USA). The impact of this system on gas exchange capacity, blood elements and hemolysis is compared to that of a conventional circuit in a model of prolonged perfusion. Methods: Twelve calves (mean body weight: 72.2±3.7 kg) were placed on cardiopulmonary bypass for 6 h with a flow of 5 l/min, and randomly assigned to the CardioVention system (n=6) or a standard CPB circuit (n=6). A standard battery of blood samples was taken before bypass and throughout bypass. Analysis of variance was used for comparison. Results: The hematocrit remained stable throughout the experiment in the CardioVention group, whereas it dropped in the standard group in the early phase of perfusion. When normalized for prebypass values, both profiles differed significantly (P<0.01). Both O₂ and CO₂ transfers were significantly improved in the CardioVention group (P=0.04 and P<0.001, respectively). There was a slightly higher pressure drop in the CardioVention group but no single value exceeded 112 mmHg. No hemolysis could be detected in either group with all free plasma Hb values below 15 mg/l. Thrombocyte count, when corrected by hematocrit and normalized by prebypass values, exhibited an increased drop in the standard group (P=0.03). Conclusion: The CardioVention system with its concept of limited priming volume and exposed foreign surface area, improves gas exchange probably because of the absence of detectable hemodilution, and appears to limit the decrease in the thrombocyte count which may be ascribed to the reduced surface. Despite the volume and surface constraints, no hemolysis could be detected throughout the 6 h full-flow perfusion period.

Key Words: Cardiopulmonary bypass • Hemodilution • Gas exchange

This article has been cited by other articles:

				A. F. Corno Systemic venous drainage: can we help Newton? Eur. J. Cardiothorac. Surg., June 1, 2007; 31(6): 1044 - 1051. [Abstract] [Full Text] [PDF]

				U. Abdel-Rahman, F. Ozaslan, P. S. Risteski, S. Martens, A. Moritz, A. Al Daraghmeh, H. Keller, and G. Wimmer-Greinecker Initial Experience With a Minimized Extracorporeal Bypass System: Is There a Clinical Benefit? Ann. Thorac. Surg., July 1, 2005; 80(1): 238 - 243. [Abstract] [Full Text] [PDF]

				J. Wippermann, J. M. Albes, M. Hartrumpf, M. Kaluza, R. Vollandt, R. Bruhin, and T. Wahlers Comparison of minimally invasive closed circuit extracorporeal circulation with conventional cardiopulmonary bypass and with off-pump technique in CABG patients: selected parameters of coagulation and inflammatory system Eur. J. Cardiothorac. Surg., July 1, 2005; 28(1): 127 - 132. [Abstract] [Full Text] [PDF]

				H. Takai, K. Eishi, S. Yamachika, S. Hazama, T. Ariyoshi, and K. Nishi Demonstration and Operative Influence of Low Prime Volume Closed Pump Asian Cardiovasc Thorac Ann, March 1, 2005; 13(1): 65 - 69. [Abstract] [Full Text] [PDF]

				M A. Huybregts, R de Vroege, H M. Christiaans, A L Smith, and R C. Paulus The use of a mini bypass system (Cobe Synergy) without venous and cardiotomy reservoir in a mitral valve repair: a case report Perfusion, March 1, 2005; 20(2): 121 - 124. [Abstract] [PDF]

				M. J. Mack Advances in the treatment of coronary artery disease Ann. Thorac. Surg., December 1, 2003; 76(6): S2240 - 2245. [Abstract] [Full Text] [PDF]

				L. K von Segesser, P. Tozzi, I. Mallbiabrrena, D. Jegger, J. Horisberger, and A. Corno Miniaturization in cardiopulmonary bypass Perfusion, July 1, 2003; 18(4): 219 - 224. [Abstract] [PDF]

				T Gourlay and P Connolly Does cardiopulmonary bypass still represent a good investment? The biomaterials perspective Perfusion, July 1, 2003; 18(4): 225 - 231. [Abstract] [PDF]

				T. Gourlay, I. Samartzis, and K. M Taylor The effect of haemodilution on blood/biomaterial contact-mediated CD11b expression on neutrophils: ex vivo studies Perfusion, March 1, 2003; 18(2): 87 - 93. [Abstract] [PDF]