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Eur J Cardiothorac Surg 2002;22:521-526
© 2002 Elsevier Science NL

Preoperative C-reactive protein level and outcome following coronary surgery

^a Department of Cardiac Surgery, Catholic University, Rome, Italy
^b Department of Cardiology, Catholic University, Rome, Italy
^c ‘Angela Valenti’ Laboratory of Genetic and Enviromental Risk Factors for Thrombotic Disease, Department of Vascular Medicine and Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy
^d Department of Cardiac Anaesthesiology, Catholic University, Rome, Italy

Received 27 March 2002; received in revised form 4 July 2002; accepted 11 July 2002.

* Corresponding author. Divisione di Cardiochirurgia, Policlinico Universitario A. Gemelli, Largo A. Gemelli 8, 00168, Rome, Italy. Tel./fax: +39-06-30-5-81-81
e-mail: mgaudino{at}tiscalinet.it

Objective: It has been suggested that a preoperative level of C-reactive protein (CRP)>5 mg/l is predictive of postoperative complications in cardiac surgery patients. Material and methods: Among 113 primary isolated coronary artery bypass patients, CRP was determined preoperatively and fibrinogen, interleukine 6, plasminogen activator inhibitor-1, prothrombin time, activated partial thromboplastin time, platelets and white blood cells count measured before surgery, 24, 48 and 72 h thereafter and at hospital discharge. The clinical course of all cases was prospectively recorded. Data were then analysed according to the preoperative CRP level by dividing the patients into two groups (CRP>5 mg/l or CRP<5 mg/l). Results: The in-hospital results were similar between the two patients groups. Even the postoperative haematic inflammatory markers did not significantly differ according to the preoperative CRP level. Conclusion: In this prospective study, a preoperative level of CRP>5 mg/l did not predict in-hospital postoperative complications nor influence the extent of the inflammatory activation in primary isolated coronary bypass patients.

Key Words: C-reactive protein • Coronary artery bypass

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