HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Mark P. Anstadt Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lee, J. R. Articles by Green, L. K. Search for Related Content PubMed PubMed Citation Articles by Lee, J. R. Articles by Green, L. K. Related Collections Mediastinum Esophagus - cancer

Eur J Cardiothorac Surg 2002;22:1014-1016
© 2002 Elsevier Science NL

Case report

Gastrointestinal stromal tumor of the posterior mediastinum

^a Veterans Affairs Medical Center, Institute of Molecular Medicine and Genetics and Department of Pathology, Medical College of Georgia, Augusta, GA, USA
^b Department of Surgery, Division of Cardiothoracic Surgery, Medical College of Georgia, Augusta, GA, USA
^c Department of Surgery, Division of Cardiothoracic Surgery, Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX, USA
^d Department of Pathology, Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX, USA

Received 27 June 2002; received in revised form 17 August 2002; accepted 23 August 2002.

* Corresponding author. Tel.: +1-706-823-2232; fax: +1-706-823-3965
e-mail: jlee{at}mail.mcg.edu

Gastrointestinal stromal tumor (GIST) is a rare, but potentially aggressive tumor. We present an asymptomatic 64-year-old man with an incidental 9-cm GIST that arose in the posterior mediastinum. Wide surgical excision was performed with rotation of an intercostal muscle flap to buttress a surgically created esophageal wall defect. The patient is now free of disease 26 months postoperative. This tumor is defined by the carcinogenic over-expression of KIT-protein, a tyrosine kinase receptor. Accurate diagnosis of gastrointestinal stromal tumor is imperative, as specific medical therapy is now available for potential control of recurrent or metastatic disease.

Key Words: Gastrointestinal stromal tumor (GIST) • Gastrointestinal autonomic nerve tumor (GANT) • KIT • Mediastinum • Esophagus

This article has been cited by other articles:

				M. G. Blum, K. Y. Bilimoria, J. D. Wayne, A. L. de Hoyos, M. S. Talamonti, and B. Adley Surgical Considerations for the Management and Resection of Esophageal Gastrointestinal Stromal Tumors Ann. Thorac. Surg., November 1, 2007; 84(5): 1717 - 1723. [Abstract] [Full Text] [PDF]

				A. Basoglu, E. Kaya, B. Celik, and L. Yildiz Giant gastrointestinal stromal tumor of the esophagus presenting with dyspnea J. Thorac. Cardiovasc. Surg., May 1, 2006; 131(5): 1198 - 1199. [Full Text] [PDF]

				A. Forsythe, J. Volpe, and R. Muller Posterior Mediastinal Ganglioneuroma RadioGraphics, March 1, 2004; 24(2): 594 - 597. [Full Text] [PDF]