HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Michal Krejca Andrzej Bochenek Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Krejca, M. Articles by Bochenek, A. Search for Related Content PubMed PubMed Citation Articles by Krejca, M. Articles by Bochenek, A. Related Collections Cardiac - other Coronary disease

Eur J Cardiothorac Surg 2002;22:898-903
© 2002 Elsevier Science NL

A new outside stent – does it prevent vein graft intimal proliferation?

^a 1st Cardiac Surgery Department, Silesian University of Medicine, SPSK nr 7, 40-635 Katowice, ul. Ziolowa 45-47, Poland
^b Department of Histology and Embryology, Silesian University of Medicine, 40-752 Katowice, ul. Medykow 18-20, Poland

Received 28 June 2002; received in revised form 5 September 2002; accepted 6 September 2002.

* Corresponding author. Tel.: +48-32-202-40-25, ext. 1640; fax: +48-32-252-70-66
e-mail: mkrejca{at}wp.pl

Objective: The saphenous vein subjected to arterial pressure stretches to its elastic limits and constitutes intimal hyperplasia. Sheathing of the vein graft with pressure-resistant tubing might prolong vein graft patency. Methods: Twenty-one sheep received radial vein grafts or hybrid grafts composed of radial vein, collagen fibrin glue and highly flexible torlen/dacron mesh tubing transplanted into the carotid artery position. Veins were examined with the use of light and electron microscopy. Proliferating cell antigen (Ki-67) stains served as markers of proliferation. Results: The mean wall thickness of both intimal and medial layers was evaluated. The mean intimal wall thickness was 19±11 µm in hybrid grafts vs. 24±7 µm in unsheathed grafts (P<0.001); 22±6 vs. 26±10 µm (P<0.001); 23±8 vs. 52±15 µm (P<0.001); 37±21 vs. 90±31 µm (P<0.001); 57±31 vs. 104±28 µm (P<0.001); 58±21 vs. 133±32 µm (P<0.001); and 72±22 vs. 244±100 µm (P<0.001) after respectively 5 days, 9 days, 4 weeks, 6 weeks, 8 weeks, 10 weeks and 12 weeks from implantation. Electronic microscope examination of hybrid grafts revealed a smooth endothelial layer with intact nuclei and an intima composed of layers of collagen and muscle fibers. In unsheathed grafts endothelial edema and nuclear destruction were observed. Conclusions: The external vein graft support with mesh tubing reduces intimal and medial layer thickening and cell proliferation in composite vein grafts transplanted in the arterial position.

Key Words: Coronary heart disease • Coronary vein graft • Hybrid graft • Remodeling • Atherosclerosis

This article has been cited by other articles:

				T. Schachner, G. Laufer, and J. Bonatti In vivo (animal) models of vein graft disease. Eur. J. Cardiothorac. Surg., September 1, 2006; 30(3): 451 - 463. [Abstract] [Full Text] [PDF]

				A. Stadnicki, E. Pastucha, G. Nowaczyk, U. Mazurek, D. Plewka, G. Machnik, T. Wilczok, and R. W. Colman Immunolocalization and expression of kinin B1R and B2R receptors in human inflammatory bowel disease Am J Physiol Gastrointest Liver Physiol, August 1, 2005; 289(2): G361 - G366. [Abstract] [Full Text] [PDF]