| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Eur J Cardiothorac Surg 2003;23:277-282
© 2003 Elsevier Science NL
a Department of Surgery and Research Center, Montreal Heart Institute, 5000 Belanger Street East, Montreal, QC, Canada H1T 1C8
b Cardiovascular Surgery Unit, Arnaud de Villeneuve Teaching Hospital, 371 Av. Doyen G. Giraud, Montpellier, 34295, France
c Department of Pathology and Research Center, Montreal Heart Institute, 5000 Belanger Street East, Montreal, QC, Canada H1T 1C8
d Department of Cardiology and Research Center, Montreal Heart Institute, 5000 Belanger Street East, Montreal, QC, Canada H1T 1C8
Received 17 September 2002; received in revised form 27 November 2002; accepted 28 November 2002.
* Corresponding author. Tel.: +1-514-376-3330x3715; fax: +1-514-376-1355
e-mail: lpperrau{at}icm.umontreal.ca
Objectives: Surgical radiofrequency ablation is increasingly used during open heart surgery for the treatment of chronic atrial fibrillation. The purpose of this study was to determine the effects of application of radiofrequency on coronary endothelial function and structure and establish the relationship between coronary lesions and distance of radiofrequency application. Methods: Six Landrace swine (25.9±2.0 kg) were included in the study. With the heart kept beating, three epicardial radiofrequency lesions (20 W, 20 s duration, 60 °C) 2 cm in length each, were created 1, 5 and 10 mm away from the left anterior descending and the right coronary arteries. The circumflex artery served as control. Coronary rings were placed in organ chambers. After contraction to KCl and prostaglandin F2
, endothelium-dependent relaxations to bradykinin were studied. Gomori trichrome and hematoxylin–eosin safran staining were used for histological evaluation. Results: Exposure to radiofrequency 1 mm from the coronary arteries caused a significant decrease in endothelium-independent contractions to KCl and endothelium-dependent relaxations to bradykinin compared to controls (P<0.05). No significant decrease of endothelium-dependent relaxations occurred for rings exposed to radiofrequency at a distance of 5 and 10 mm, compared to controls. Histological examination showed endothelial disruption and medial smooth muscle cells at different stages of necrosis up to 5 mm from the radiofrequency application site. Conclusions: Radiofrequency may induce coronary endothelial functional and morphological damages when applied less than 5 mm from the artery. Caution must be exerted during left atrial radiofrequency application due to the proximity of the circumflex artery.
Key Words: Coronary endothelial injury • Radiofrequency • Ablation atrial fibrillation
This article has been cited by other articles:
|
|
 |
|
  K. C. Roberts-Thomson, D. Steven, J. Seiler, K. Inada, B. A. Koplan, U. B. Tedrow, L. M. Epstein, and W. G. Stevenson Coronary Artery Injury Due to Catheter Ablation in Adults: Presentations and Outcomes Circulation, October 13, 2009; 120(15): 1465 - 1473. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. Aliot, W. G. Stevenson, J. M. Almendral-Garrote, F. Bogun, C. H. Calkins, E. Delacretaz, P. D. Bella, G. Hindricks, P. Jais, M. E. Josephson, et al. EHRA/HRS Expert Consensus on Catheter Ablation of Ventricular Arrhythmias: Developed in a partnership with the European Heart Rhythm Association (EHRA), a Registered Branch of the European Society of Cardiology (ESC), and the Heart Rhythm Society (HRS); in collaboration with the American College of Cardiology (ACC) and the American Heart Association (AHA) Europace, June 1, 2009; 11(6): 771 - 817. [Full Text] [PDF]
|
|
|
|
 |
|
 R. K. Voeller, R. B. Schuessler, and R. J. Damiano Jr. Surgical Treatment of Atrial Fibrillation Card. Surg. Adult, January 1, 2008; 3(2008): 1375 - 1394. [Full Text]
|
|
|
|
|
|
H. Calkins, J. Brugada, D. L. Packer, R. Cappato, S.-A. Chen, H. J.G. Crijns, R. J. Damiano Jr, D. W. Davies, D. E. Haines, M. Haissaguerre, et al. HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: Recommendations for Personnel, Policy, Procedures and Follow-Up: A report of the Heart Rhythm Society (HRS) Task Force on Catheter and Surgical Ablation of Atrial Fibrillation Developed in partnership with the European Heart Rhythm Association (EHRA) and the European Cardiac Arrhythmia Society (ECAS); in collaboration with the American College of Cardiology (ACC), American Heart Association (AHA), and the Society of Thoracic Surgeons (STS). Endorsed and Approved by the governing bodies of the American College of Cardiology, the American Heart Association, the European Cardiac Arrhythmia Society, the European Heart Rhythm Association, the Society of Thoracic Surgeons, and the Heart Rhythm Society. Europace, June 1, 2007; 9(6): 335 - 379. [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Lall, S. J. Melby, R. K. Voeller, A. Zierer, M. S. Bailey, T. J. Guthrie, M. R. Moon, N. Moazami, J. S. Lawton, and R. J. Damiano Jr The effect of ablation technology on surgical outcomes after the Cox-maze procedure: A propensity analysis J. Thorac. Cardiovasc. Surg., February 1, 2007; 133(2): 389 - 396. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Kirsh, G. J. Gross, S. O'Connor, R. M. Hamilton, and Cryocath International Patient Registry Transcatheter cryoablation of tachyarrhythmias in children: Initial experience from an international registry J. Am. Coll. Cardiol., January 4, 2005; 45(1): 133 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Khargi, A. Laczkovics, K. Muller, and T. Deneke A possible surgical technique to avoid esophageal and circumflex artery injuries using radiofrequency ablation to treat atrial fibrillation Interactive CardioVascular and Thoracic Surgery, June 1, 2004; 3(2): 352 - 355. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
