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Eur J Cardiothorac Surg 2003;23:341-346
© 2003 Elsevier Science NL

Intermittent antegrade warm myocardial protection compared to intermittent cold blood cardioplegia in elective coronary surgery – do we have to change?

Department of Cardiothoracic and Vascular Surgery, Friedrich-Schiller-University, Bachstrasse 18, Postfach, D-07740 Jena, Germany

Received 26 July 2002; received in revised form 18 November 2002; accepted 8 December 2002.

^* Corresponding author. Tel.: +49-3641-934-801; fax: +49-3641-934-802
e-mail: ulrich.franke{at}med.uni-jena.de

Objective: Intermittent antegrade warm blood cardioplegia (IAWBC) is a simple and cost-effective method of myocardial preservation. However, there are only few prospective trials comparing this type of cardioplegia to established cardioplegic strategies in elective on-pump coronary surgery with respect to myocardial protection and outcome. Methods: In a prospective, randomized trial IAWBC (33°C) (n=100) was compared to intermittent antegrade cold (4°C) blood cardioplegia (n=100), regarding clinical outcome and myocardial protection using cardiac troponin-I (cTNI) and creatine kinase MB isoenzyme (CK-MB) measurements to assess ischemia. Results: Preoperative parameters were comparable in both groups. Results demonstrated no differences in-between the groups regarding mortality (2.0% both), incidence of perioperative myocardial infarction (2 versus 3%), need for intra-aortic balloon pump (3 versus 4%), length of ICU stay (2.0±2.5 versus 2.1±3.0 days) and incidence of postoperative atrial fibrillation (41 versus 34%). However, the necessity of defibrillation after cardiac arrest (18 versus 43%, P<0.001) was significantly less frequent and of lower intensity (3.4±10.8 versus 10.8±20.6 J, P<0,001) in the IAWBC-group. Postoperatively the ischemia markers were significantly lower in the IAWBC-group, cTNI within the first 72 h (from P<0.001 to P=0.013) and even CK-MB within the first 24 h (from P=0.004 to P<0.011). Conclusion: IAWBC is a safe and simple method in elective on-pump coronary artery bypass surgery. Significantly lower ischemic markers suggest an improved myocardial protection compared to cold blood cardioplegia in these patients.

Key Words: Myocardial protection • Coronary surgery • Warm blood cardioplegia • Cold blood cardioplegia • Cardiac troponin I

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