HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Martin-Ucar, A.E. Articles by Waller, D.A. Search for Related Content PubMed PubMed Citation Articles by Martin-Ucar, A.E. Articles by Waller, D.A. Related Collections Lung - cancer Chest wall

Eur J Cardiothorac Surg 2003;23:859-864
© 2003 Elsevier Science NL

En-bloc chest wall and lung resection for non-small cell lung cancer. Predictors of 60-day non-cancer related mortality

Department of Thoracic Surgery, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK

Received 31 October 2002; received in revised form 18 February 2003; accepted 20 February 2003.

^* Corresponding author. Tel.: +44-116-256-3959; fax: +44-116-236-7768
e-mail: debra.grew{at}uhl-tr.nhs.uk

Objective: Predictors for early mortality after isolated pulmonary resection have been identified and clear guidelines regarding fitness for surgery have been produced. However, the additional risk of en-bloc chest wall resection has not been extensively studied. Aim: We analyzed our total experience of combined chest wall and lung resection for non-small-cell lung cancer (NSCLC) to identify additional risk factors for early non-tumour related mortality. Patients and methods: A retrospective review of 41 consecutive patients, with median age of 69 (range 37–84) years, operated by a single surgeon over a 4-year period. Univariate analysis was performed to assess the relationship of selected preoperative and operative variables on mortality within 2 months from surgery. Results: Low preoperative body mass index, age over 75 years, and preoperative FEV₁ of less than 70% of predicted were associated with a significantly increased 60-day mortality. In those patients with any of these risk factors 60-day mortality was 47% (8 of 17). In those with none of the above there was no mortality (of 24 patients) (P=0.0004). Discussion: En-bloc pulmonary and chest wall resection for NSCLC should be avoided in the elderly, those with limited respiratory reserve or significant weight loss. These factors render the patient highly susceptible to chest complications leading to increased mortality.

Key Words: Prognostic factors • Locally advanced lung cancer • Malnutrition • Elderly

This article has been cited by other articles:

				T. C. Mineo, V. Ambrogi, E. Pompeo, and A. Baldi Immunohistochemistry-detected microscopic tumor spread affects outcome in en-bloc resection for T3-chest wall lung cancer Eur. J. Cardiothorac. Surg., June 1, 2007; 31(6): 1120 - 1124. [Abstract] [Full Text] [PDF]

				A. Iwasaki, T. Shirakusa, T. Maekawa, S. Enatsu, and S. Maekawa Clinical evaluation of systemic inflammatory response syndrome (SIRS) in advanced lung cancer (T3 and T4) with surgical resection Eur. J. Cardiothorac. Surg., January 1, 2005; 27(1): 14 - 18. [Abstract] [Full Text] [PDF]