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Eur J Cardiothorac Surg 2003;23:907-916
© 2003 Elsevier Science NL

Review

Cell transplantation to improve ventricular function in the failing heart

Division of Cardiovascular Surgery, Toronto General Hospital, Department of Surgery, University of Toronto, Toronto, Ontario Canada

Received 13 December 2002; received in revised form 26 February 2003; accepted 27 February 2003.

^* Corresponding author. 13EN-239, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario Canada M5G 2C4. Tel.: +1-416-340-4074; fax: +1-416-340-3803
e-mail: terry.yau{at}utoronto.ca

Current therapies for congestive heart failure are limited in efficacy or in applicability. Cardiac cell transplantation offers a novel therapeutic approach to improve heart function. Although significant progress has been made over the past decade in the development of cell transplantation, only recently have investigators studied the changes in ventricular function following cell transplantation. This review article describes the latest research developments, evaluates recent studies of ventricular function after cell transplantation, and discusses the future directions of cell transplantation as a new therapy to ‘repair broken hearts’.

Key Words: Cell transplantation • Ventricular function • Congestive heart failure

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