EJCTS Click here to go to Edwards website
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Paolo Biglioli
Francesco Alamanni
Massimo Porqueddu
Marco Zanobini
Alessandro Parolari
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Biglioli, P.
Right arrow Articles by Parolari, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Biglioli, P.
Right arrow Articles by Parolari, A.
Related Collections
Right arrow Coronary disease
Right arrow Extracorporeal circulation
Right arrow Minimally invasive surgery
Right arrow Molecular biology

Eur J Cardiothorac Surg 2003;24:260-269
© 2003 Elsevier Science NL

Review

Biological effects of off-pump vs. on-pump coronary artery surgery: focus on inflammation, hemostasis and oxidative stress

Paolo Biglioli, Aldo Cannata, Francesco Alamanni, Moreno Naliato, Massimo Porqueddu, Marco Zanobini, Elena Tremoli, Alessandro Parolari*

Department of Cardiac Surgery, Centro Cardiologico Monzino IRCCS, University of Milan, via Parea 4, 20138 Milan, Italy

Received 30 July 2002; received in revised form 15 April 2003; accepted 24 April 2003.

* Corresponding author. Tel.: +39-02-58002558; fax: +39-02-58011194
e-mail: aparolari{at}cardiologicomonzino.it

Cardiopulmonary bypass (CPB) has been recognized as a cause of complex systemic inflammatory response, which significantly contributes to several adverse postoperative complications. In the last few years, off-pump coronary artery bypass grafting has gained widespread diffusion as an alternative technique to conventional on-pump coronary artery bypass grafting. Surgeons supporting off-pump surgery state that the avoidance of the CPB and myocardial ischemia-reperfusion significantly reduces the postoperative systemic inflammatory response and other biological derangements and, possibly, may improve the clinical outcomes. We review, here, the available evidence concerning possible differences between off-pump and on-pump procedures in terms of inflammation, hemostasis and oxidative stress. Consistent differences in the involvement of these systems are observed, but they are limited to the final steps of the surgical procedures and the early hours after. These findings suggest that the global surgical trauma may be as important, or even more, as the CPB in terms of systemic inflammatory and coagulation–fibrinolytic pathway activation. Further studies are needed in order to confirm this hypothesis.

Key Words: Cardiopulmonary bypass • Coronary surgery • Beating heart surgery • Inflammation • Hemostasis • Oxidative stress




This article has been cited by other articles:


Home page
 Eur. J. Cardiothorac. Surg.Home page
W. J. Gomes and P. R. Evora
Vasoplegic syndrome after off-pump coronary artery bypass surgery: a rising threat
Eur. J. Cardiothorac. Surg., June 1, 2009; 35(6): 1116 - 1117.
[Full Text] [PDF]

Home page
 Br J AnaesthHome page
J. E. Cho, J. K. Shim, Y. S. Choi, D. H. Kim, S. W. Hong, and Y. L. Kwak
Effect of low-dose ketamine on inflammatory response in off-pump coronary artery bypass graft surgery
Br. J. Anaesth., January 1, 2009; 102(1): 23 - 28.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
R. Chenevard, Y. Suter, and P. Erne
Effects of the heart-lung machine on melatonin metabolism and mood disturbances.
Eur. J. Cardiothorac. Surg., August 1, 2008; 34(2): 338 - 343.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
M. Di Mauro and A. M. Calafiore
Reply
Ann. Thorac. Surg., July 1, 2008; 86(1): 350 - 350.
[Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
F. Alamanni, L. Dainese, M. Naliato, S. Gregu, M. Agrifoglio, G. L. Polvani, P. Biglioli, A. Parolari, and for the Monzino OPCAB Investigators
On- and off-pump coronary surgery and perioperative myocardial infarction: an issue between incomplete and extensive revascularization.
Eur. J. Cardiothorac. Surg., July 1, 2008; 34(1): 118 - 126.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
A. Castellheim, T. N. Hoel, V. Videm, E. Fosse, A. Pharo, J. L. Svennevig, A. E. Fiane, and T. E. Mollnes
Biomarker Profile in Off-Pump and On-Pump Coronary Artery Bypass Grafting Surgery in Low-Risk Patients
Ann. Thorac. Surg., June 1, 2008; 85(6): 1994 - 2002.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
J. L. Rudolph, B. Ramlawi, G. A. Kuchel, J. E. McElhaney, D. Xie, F. W. Sellke, K. Khabbaz, S. E. Levkoff, and E. R. Marcantonio
Chemokines Are Associated With Delirium After Cardiac Surgery
J. Gerontol. A Biol. Sci. Med. Sci., February 1, 2008; 63(2): 184 - 189.
[Abstract] [Full Text] [PDF]

Home page
 ICVTSHome page
T. Vanek, M. Jares, J. Snircova, and M. Maly
Fibrinolysis in coronary artery surgery: detection by thromboelastography
Interactive CardioVascular and Thoracic Surgery, December 1, 2007; 6(6): 700 - 704.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
A. Radaelli, C. Loardi, M. Cazzaniga, G. Balestri, C. DeCarlini, M. G. Cerrito, E. N. Cusa, L. Guerra, S. Garducci, D. Santo, et al.
Inflammatory Activation During Coronary Artery Surgery and Its Dose-Dependent Modulation by Statin/ACE-Inhibitor Combination
Arterioscler Thromb Vasc Biol, December 1, 2007; 27(12): 2750 - 2755.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
M. Di Mauro, M. Gagliardi, A. L. Iaco, M. Contini, A. Bivona, P. Bosco, S. Gallina, and A. M. Calafiore
Does Off-Pump Coronary Surgery Reduce Postoperative Acute Renal Failure? The Importance of Preoperative Renal Function
Ann. Thorac. Surg., November 1, 2007; 84(5): 1496 - 1502.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
A. Parolari, M. Camera, F. Alamanni, M. Naliato, G. L. Polvani, M. Agrifoglio, M. Brambilla, C. Biancardi, L. Mussoni, P. Biglioli, et al.
Systemic Inflammation After On-Pump and Off-Pump Coronary Bypass Surgery: A One-Month Follow-Up
Ann. Thorac. Surg., September 1, 2007; 84(3): 823 - 828.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
A. M. Draaisma, M. G. Hazekamp, N. Anes, P. H. Schoof, C. E. Hack, A. Sturk, and R. A.E. Dion
Phosphorylcholine Coating of Bypass Systems Used for Young Infants Does Not Attenuate the Inflammatory Response
Ann. Thorac. Surg., April 1, 2006; 81(4): 1455 - 1459.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
V. Cavalca, E. Sisillo, F. Veglia, E. Tremoli, G. Cighetti, L. Salvi, A. Sola, L. Mussoni, P. Biglioli, G. Folco, et al.
Isoprostanes and Oxidative Stress in Off-Pump and On-Pump Coronary Bypass Surgery
Ann. Thorac. Surg., February 1, 2006; 81(2): 562 - 567.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
W. Hassanein, A. A. Albert, B. Arnrich, J. Walter, I. C. Ennker, U. Rosendahl, S. Bauer, and J. Ennker
Intraoperative Transit Time Flow Measurement: Off-Pump Versus On-Pump Coronary Artery Bypass
Ann. Thorac. Surg., December 1, 2005; 80(6): 2155 - 2161.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
A. Parolari, L. Mussoni, M. Frigerio, M. Naliato, F. Alamanni, G. L. Polvani, M. Agrifoglio, F. Veglia, E. Tremoli, P. Biglioli, et al.
The role of tissue factor and P-selectin in the procoagulant response that occurs in the first month after on-pump and off-pump coronary artery bypass grafting
J. Thorac. Cardiovasc. Surg., December 1, 2005; 130(6): 1561 - 1566.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
T. Vanek, M. Jares, R. Fajt, Z. Straka, K. Jirasek, M. Kolesar, P. Brucek, and M. Maly
Fibrinolytic inhibitors in off-pump coronary surgery: a prospective, randomized, double-blind TAP study (tranexamic acid, aprotinin, placebo)
Eur. J. Cardiothorac. Surg., October 1, 2005; 28(4): 563 - 568.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
A. Parolari, L. Mussoni, M. Frigerio, M. Naliato, F. Alamanni, A. Galanti, G. Fiore, F. Veglia, E. Tremoli, P. Biglioli, et al.
Increased prothrombotic state lasting as long as one month after on-pump and off-pump coronary surgery
J. Thorac. Cardiovasc. Surg., August 1, 2005; 130(2): 303 - 308.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
A. Weerasinghe, T. Athanasiou, S. Al-Ruzzeh, R. Casula, P. P. Tekkis, M. Amrani, P. Punjabi, K. Taylor, R. Stanbridge, and B. Glenville
Functional Renal Outcome in On-Pump and Off-Pump Coronary Revascularization: A Propensity-Based Analysis
Ann. Thorac. Surg., May 1, 2005; 79(5): 1577 - 1583.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
C. R. Luyten, F. J. van Overveld, L. A. De Backer, A. M. Sadowska, I. E. Rodrigus, S. G. De Hert, and W. A. De Backer
Antioxidant defence during cardiopulmonary bypass surgery
Eur. J. Cardiothorac. Surg., April 1, 2005; 27(4): 611 - 616.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
L. K. von Segesser
Creating innovative departments
Eur. J. Cardiothorac. Surg., December 1, 2004; 26(Suppl_1): S78 - S81.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
A. Cannata, P. Biglioli, E. Tremoli, and A. Parolari
Biological effects of coronary surgery: role of surgical trauma and CPB
Eur. J. Cardiothorac. Surg., September 1, 2004; 26(3): 664 - 664.
[Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
S. G. Raja
The 'dark side' of cardiopulmonary bypass
Eur. J. Cardiothorac. Surg., May 1, 2004; 25(5): 906 - 906.
[Full Text] [PDF]

Home page
 Anesth. Analg.Home page
V. Casati, S. Benussi, L. Sandrelli, M. A. Grasso, S. Spagnolo, and A. D'Angelo
Intraoperative Moderate Acute Normovolemic Hemodilution Associated with a Comprehensive Blood-Sparing Protocol in Off-Pump Coronary Surgery
Anesth. Analg., May 1, 2004; 98(5): 1217 - 1223.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2003 European Association for Cardio-Thoracic Surgery. Published by Elsevier. All rights reserved.