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Eur J Cardiothorac Surg 2003;24:441-449
© 2003 Elsevier Science NL

Prognostic significance of E-cadherin and ß-catenin in resected stage I non-small cell lung cancer

^a Department of Thoracic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
^b Samsung Biomedical Research Institute, Seoul, South Korea
^c Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

Received 3 February 2003; received in revised form 21 April 2003; accepted 28 April 2003.

e-mail: ysooyah{at}yahoo.co.kr
^* Corresponding author. Samsung Medical Center, 50 Ilwondong Kangnam-Gu Seoul, 135-710 South Korea. Tel.: +82-2-3410-3483; fax: +82-2-3410-1680
e-mail: jkim{at}smc.samsung.co.kr

Objectives: E-cadherin and its associated intracellular molecules, catenins, are important for cell–cell adhesion. Impaired expression of these molecules are frequently observed in several cancers. E-cadherin and ß-catenin are often expressed in non-small cell lung cancers. The aim of this study was to investigate the expressions of E-cadherin and ß-catenin and their significance as prognostic markers in pathological stage I non-small cell lung cancer. Methods: Paraffin embedded tumor tissue blocks were obtained from 141 patients who underwent resection without preoperative radiotherapy or chemotherapy with pathological stage I non-small cell lung cancer. Tumor samples were prepared in tissue microarrays and they were stained by immunohistochemistry with antibodies against E-cadherin and ß-catenin. The expressions of E-cadherin and ß-catenin were analyzed with relation to the clinico-pathological data. The median follow-up period of the patients was 41 months (range, 2–88 months). Results: Preserved expressions of E-cadherin and ß-catenin were observed in the membrane and the cytoplasm of normal epithelial cells and tumor cells. Absent or reduced expression for E-cadherin and ß-catenin were observed in 60% and 45% of all the patients, respectively. There was a significant positive correlation between E-cadherin and ß-catenin expression (P<0.01). Absent or reduced expression of E-cadherin was observed in 72.5%, 36.6%, and 60.0% of squamous cell carcinoma, adenocarcinoma, and bronchioloalveolar carcinoma, respectively. There was a significant decrease of E-cadherin expression in squamous cell carcinoma compared to adenocarcinoma (P<0.01). Patients with reduced expression of ß-catenin had poor recurrence free survival in adenocarcinoma, but not in squamous cell carcinoma. Conclusion: Decreased expressions of E-cadherin and ß-catenin were closely correlated in resected stage I non-small cell lung cancer. Reduced expression of E-cadherin and ß-catenin indicates tumor cell dedifferentiation and reduced expression of ß-catenin had poor recurrence free survival in adenocarcinoma of the resected stage I non-small cell lung cancer.

Key Words: Lung cancer • Immunohistochemistry • E-cadherin • ß-Catenin • Tissue microarray

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