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Eur J Cardiothorac Surg 2003;24:837-839
© 2003 Elsevier Science NL

Case report

Successful weaning from inhaled nitric oxide using dipyridamole

Department of Cardiovascular Surgery, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan

Received 13 May 2003; received in revised form 14 July 2003; accepted 15 July 2003.

^* Corresponding author. Tel.: +22-717-7222; fax: +22-717-7227
e-mail: ysaiki{at}mail.cc.tohoku.ac.jp

A 33-year-old woman with an atrial septal defect associated with severe pulmonary hypertension underwent suture closure of the defect after assessment of operability by lung biopsy. Postoperative course was complicated by suprasystemic refractory pulmonary hypertension, and she became dependent upon treatment with inhaled nitric oxide. After multiple attempts to withdraw nitric oxide, dipyridamole was administered and blunted the rebound pulmonary hypertension after subsequent nitric oxide withdrawal.

Key Words: Nitric oxide • Pulmonary hypertension • Dipyridamole

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