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Eur J Cardiothorac Surg 2004;25:160-166
© 2004 Elsevier Science NL
a Department of Cardiothoracic Surgery, University of Vienna, Währinger Gürtel 18-20, Vienna A-1090, Austria
b Thoracic Surgery Clinic, Korányi National Institute for Pulmonology, Budapest, Hungary
c Ruhrland Clinic, Essen, Germany
d Central Clinic, Augsburg, Germany
e University Hospital, Uppsala, Sweden
Received 8 August 2003; received in revised form 11 November 2003; accepted 16 November 2003.
* Corresponding author. Tel.: +43-1-40-400-5644; fax: +43-1-40-400-5642
e-mail: walter.klepetko{at}akh-wien.ac.at
Objective: Persisting air leakage after pulmonary resection remains a significant problem. The aim of the study was to evaluate the incidence of air leakage after standard lobectomy and test the efficacy and safety of TachoComb (TC). Methods: A total of 189 patients undergoing lobectomy were enrolled in a multi-centre, open, randomised, and prospective study to test the efficacy and safety of TachoComb (TC) for air leakage treatment. Air leakage was assessed by water submersion test, and scored as grades 0 if no, 1 if countable, 2 if a stream of and 3 if coalescent bubbles have been observed. Any sites with grade 3 air leakage received further stapling or limited suturing until grade 0, 1 or 2 was obtained. Treatment of air leakage was done with TC or suturing according to randomisation. Air leakage was assessed by further submersion tests. Postoperative air leakage was assessed using the Pleur-Evac system. Results: Overall incidence of air leakage 48±6 h after surgery was 34% for TC and 37% for standard treatment (P=0.76). The reduction of intra-operative air leak intensity in the subgroup with grades 1–2 was significantly higher for the TC group (P=0.015). Postoperative air leakage intensity in the subgroup with air leakage grades 1–2 was lower for TC than standard treatment (P=0.047). The mean duration of postoperative air leakage in the subgroup with grades 1–2 was shorter for the TC group than for standard treatment, i.e. 1.9±1.4 vs. 2.7±2.2 days (P=0.015). Conclusions: TC could be proven as well-tolerated and safe. In the subgroup of patients with established air leakage, TC showed superior potential in reduction of intra-operative air leakage as well as in reduction of intensity and duration of postoperative air leakage.
Key Words: Air leakage • Lung tissue sealing • TachoComb
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