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Eur J Cardiothorac Surg 2004;25:468-470
© 2004 Elsevier Science NL

Case report

Successful CABG in a patient with paroxysmal nocturnal hemoglobinuria

Department of Cardiovascular Surgery, Yamanashi Central Hospital, 1-1-1, Fujimi, Kofu-shi, Yamanashi 400-0027, Japan

Received 11 June 2003; received in revised form 4 October 2003; accepted 24 November 2003.

^* Corresponding author. Tel.: +81-55-253-7111; fax: +81-55-253-8011
e-mail: ujinaito{at}aol.com

Paroxysmal nocturnal hemoglobinuria (PNH) is an uncommon acquired disorder of blood cells characterized by intravascular hemolysis due to an inordinate sensitivity to complement-mediated membrane damage. This report documents coronary artery revascularization in a patient with PNH, which has not been described in the literature so far. We used the on-pump procedure in the present patient and successfully performed revascularization by taking prophylactic measures against hemolysis.

Key Words: Paroxysmal nocturnal hemoglobinuria • Coronary artery bypass grafting • Complement • Hemolysis • On-pump

This article has been cited by other articles:

				K. Knobloch, A. Lichtenberg, J. Schubert, and A. Haverich Paroxysmal nocturnal hemoglobinuria - pre- and perioperative rationale during cardiac surgery using extracorporeal circulation Eur. J. Cardiothorac. Surg., November 1, 2004; 26(5): 1058 - 1059. [Full Text] [PDF]

				Y. Naito, M. Nakajima, H. Inoue, and K. Tsuchiya Cardiac surgery in patients with hematological disorders Eur. J. Cardiothorac. Surg., November 1, 2004; 26(5): 1059 - 1060. [Full Text] [PDF]