HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Erkan Yildirim Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Yildirim, E. Articles by Sakinci, U. Search for Related Content PubMed PubMed Citation Articles by Yildirim, E. Articles by Sakinci, U. Related Collections Lung - cancer Pleura Education

Eur J Cardiothorac Surg 2005;27:19-22
© 2005 Elsevier Science NL

Rapid pleurodesis in symptomatic malignant pleural effusion

^a Department of Thoracic Surgery, Ankara Numune Education and Research Hospital, Ankara, Turkey
^b Department of Medical Oncology, Ankara Numune Education and Research Hospital, Ankara, Turkey

Received 30 June 2004; received in revised form 5 August 2004; accepted 17 August 2004.

^* Corresponding author. Asagiövecler Mh. 79.Sk. 8/3 06460 Dikmen-Cankaya, Ankara, Turkey. Tel.: +90 312 482 72 79; fax: +90 312 310 34 60. (E-mail: erseyda{at}yahoo.com).

Objective: The objective of the study was to see whether a rapid method of pleurodesis was superior to the standard protocol in patients with symptomatic malignant pleural effusion. Methods: Between January 2000 and February 2003, a prospective randomised trial was carried out in a sequential sample of 27 patients with malignant pleural effusions documented cytopathologically. Twelve patients were allocated to group 1 (standard protocol) and 15 to group 2 (new protocol). A small-bore catheter (12Fr) and oxytetracycline (35mg/kg of body weight) were used in both groups. In group 1, patients had drainage until radiological evidence of lung re-expansion was obtained and the amount of fluid drained was less than 150ml/day, before oxytetracycline was instilled. The catheter was removed when the amount of fluid drained after instillation was less than 150ml/day. In group 2, patients had the oxytetracycline instilled in a fractionated-dose manner following frequent aspirations at 6h intervals. The catheter was removed when the total amount of fluid drained after instillation of the oxytetracycline [OT] was less than 150ml/last three aspirations. Response was evaluated at 1, 3 and 6 months after pleurodesis. Results: There was no statistically significant difference in the demographic features, site of the primary tumour, disease characteristics, and response rates in any evaluation period in both groups (P>0.05). However, the number of days of drainage and hospitalisation, and the cost were significantly lower in the second group (P<0.001). Conclusions: This new pleurodesis method provided shorter hospital stay resulting in superior cost-effectiveness and palliation without sacrificing the efficacy of pleurodesis.

Key Words: Pleural diseases • Pleurisies • Malignant pleural effusion • Pleurodesis • Methods • Efficacy • Treatment

This article has been cited by other articles:

				J. A. Burgers, P. W. A. Kunst, M. G. J. Koolen, L. N. A. Willems, J. S. Burgers, and M. van den Heuvel Pleural drainage and pleurodesis: implementation of guidelines in four hospitals Eur. Respir. J., November 1, 2008; 32(5): 1321 - 1327. [Abstract] [Full Text] [PDF]

				J. E. Heffner and J. S. Klein Recent Advances in the Diagnosis and Management of Malignant Pleural Effusions Mayo Clin. Proc., February 1, 2008; 83(2): 235 - 250. [Abstract] [Full Text] [PDF]