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Eur J Cardiothorac Surg 2005;27:611-616
© 2005 Elsevier Science NL

Antioxidant defence during cardiopulmonary bypass surgery

^a Department of Respiratory Medicine, University of Antwerp, Universiteitsplein 1, B-2610 Antwerpen-Wilrijk, Belgium
^b Department of Cardiac Surgery, University Hospital Antwerp, Antwerpen-Wilrijk, Belgium
^c Department of Anesthesiology, University Hospital Antwerp, Antwerpen-Wilrijk, Belgium

Received 15 July 2004; received in revised form 3 December 2004; accepted 13 December 2004.

^* Corresponding author. Tel: +32 3 820 2591; fax: +32 3 820 2590. (E-mail: anna.sadowska{at}ua.ac.be).

Objective: Cardiac surgery may lead to severe oxidative stress due to formation of oxidation products generated during ischemia and reperfusion. We investigated to which extent oxidative stress influences a number of endogenous antioxidants and markers of cellular activation. Methods: At six time points blood was withdrawn from patients undergoing coronary artery bypass grafting, using the on-pump procedure. Results: Both glutathione peroxidase and superoxide dismutase show a gradual and strong increase in activity during surgery (40 and 30%, respectively), returning to baseline values 24h after surgery. The total antioxidant capacity has a maximum increase of 60%. Markers of cellular activation, such as eosinophil cationic protein and tryptase also increase during the procedure. Conclusion: Cardiac surgery results in systemic inflammation accompanied or caused by severe oxidative stress. The human body has a strong innate oxidative defence screen, which is probably not sufficient to fully compensate for the total amount of oxidative damage.

Key Words: Bypass surgery • Antioxidants • Glutathione peroxidase • Superoxide dismutase • Oxidative stress

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