HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Didier Lardinois Walter Weder Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lardinois, D. Articles by Weder, W. Search for Related Content PubMed PubMed Citation Articles by Lardinois, D. Articles by Weder, W. Related Collections Lung - transplantation

Eur J Cardiothorac Surg 2005;27:762-767
© 2005 Elsevier Science NL

Extended donor lungs: eleven years experience in a consecutive series

^a Division of Thoracic Surgery, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland
^b Department of Biostatistics, University of Zurich, Zurich, Switzerland
^c Division of Pneumology, University Hospital, Zurich, Switzerland
^d Department of Medicine, University Hospital, Zurich, Switzerland

Received 12 September 2004; received in revised form 23 December 2004; accepted 12 January 2005.

^* Corresponding author. Tel.: +41 1 2558802; fax: +41 1 2558805. (E-mail: walter.weder{at}usz.ch).

Objective: The aim of this study was to delineate the profile of extended donor lungs in comparison to ideal donor lungs and to analyse their outcome. Particular attention was given to donor lungs with a low PaO₂ (<250mmHg) before harvesting or with multiple extended criteria. Methods: Between 1993 and 2003, 148 patients (79 women, 69 men, mean age 39.9 years) underwent lung transplantation. Indications were cystic fibrosis in 35.8%, emphysema in 26.4%, pulmonary fibrosis in 12.2%, pulmonary hypertension in 9.5%, and others in 16.1%. Donor data and recipients medical files were reviewed. Criteria for donor lungs were considered extended if one or more of the following criteria were met: age >55 years, smoking >20 pack-years, PaO₂ before harvesting <300mmHg, pathologic chest X-ray, and purulent secretion at bronchoscopy. A comparison between recipients from ideal and from extended donor lungs was performed with respect to the median duration of mechanical ventilation, the median length of stay at the intensive care unit, postoperative complications, the 30-day and the 1-year survival, and the 6-month follow-up spirometry. Results: Sixty-three (42.6%) donor lungs were considered extended and 20 (31.7%) met more than one criteria. Outcome comparison between recipients from ideal (I) and extended (II) donor lungs did not statistically differ in postoperative complications (18.8% (I) vs. 26.9% (II), P=0.32), mean duration of mechanical ventilation (d) (4.4±2.7 (I) vs. 2.6±2.1 (II), P=0.2), mean length of stay at the ICU (d) (11.5±8.8 (I) vs. 9.2±6.9 (II), P=0.4), 6-month pulmonary function (FEV1=83±23% of the predicted value (I) vs. 82±18% (II), P=0.81), 30-day survival (90.6% (I) vs. 93.7% (II), P=0.56), 1-year survival (83.5% (I) vs. 81% (II), P=0.83). Thirty-day survival was also comparable even in recipients from donor lungs with PaO₂<250mmHg (n=8) (90.6% (I) vs. 87.5%, P=0.57). The number of extended criteria had no impact on the outcome. The combination of PaO₂<300mmHg with purulent secretion at bronchoscopy seemed to influence the early outcome of recipients from extended donor lungs negatively. Conclusions: Our results suggest that the use of selected extended donor lungs does not compromise the outcome after transplantation. PaO₂ <250mmHg before harvesting of the lungs is not an absolute contra-indication for transplantation.

Key Words: Lung transplantation • Extended donor lungs • Outcome

This article has been cited by other articles:

				T. Oto, B. J. Levvey, H. Whitford, A. P. Griffiths, T. Kotsimbos, T. J. Williams, and G. I. Snell Feasibility and Utility of a Lung Donor Score: Correlation With Early Post-Transplant Outcomes Ann. Thorac. Surg., January 1, 2007; 83(1): 257 - 263. [Abstract] [Full Text] [PDF]

				P. Botha, D. Trivedi, C. P. Searl, P. A. Corris, S. V.B. Schueler, and J. H. Dark Differential Pulmonary Vein Gases Predict Primary Graft Dysfunction Ann. Thorac. Surg., December 1, 2006; 82(6): 1998 - 2002. [Abstract] [Full Text] [PDF]

				D. C. McGiffin Invited commentary Ann. Thorac. Surg., December 1, 2006; 82(6): 2002 - 2003. [Full Text] [PDF]

				L. F. Angel, D. J. Levine, M. I. Restrepo, S. Johnson, E. Sako, A. Carpenter, J. Calhoon, J. E. Cornell, S. G. Adams, G. B. Chisholm, et al. Impact of a Lung Transplantation Donor-Management Protocol on Lung Donation and Recipient Outcomes Am. J. Respir. Crit. Care Med., September 15, 2006; 174(6): 710 - 716. [Abstract] [Full Text] [PDF]

				P. Botha, D. Trivedi, C. J. Weir, C. P. Searl, P. A. Corris, J. H. Dark, and S. V.B. Schueler Extended donor criteria in lung transplantation: Impact on organ allocation J. Thorac. Cardiovasc. Surg., May 1, 2006; 131(5): 1154 - 1160. [Abstract] [Full Text] [PDF]

				O. Ashraf Unexpected pulmonary embolism in lung transplantation: Diagnosis and prospects J. Thorac. Cardiovasc. Surg., April 1, 2006; 131(4): 930 - 930. [Full Text] [PDF]