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Eur J Cardiothorac Surg 2005;27:1036-1042
© 2005 Elsevier Science NL

Review

Fetal origins of coronary heart disease—implications for cardiothoracic surgery?

Omar A. Khana,b,*, Ryan Chaua,b, Caroline Bertramb, Mark A. Hansonb, Sunil K. Ohria

a Department of Cardiothoracic Surgery, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
b Centre for Developmental Origins of Health and Disease, University of Southampton, Southampton, UK

Received 23 November 2004; received in revised form 16 January 2005; accepted 17 January 2005.

* Corresponding author. Address: Department of Cardiothoracic Surgery, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK. Tel.: +44 2380 798 421; fax: +44 2380 786 933. (E-mail: omarkhan{at}iname.com).

Over the last 15 years, there has been growing evidence that poor nutrition during gestation plays an important role in the development of coronary heart disease. This hypothesis, commonly known as the ‘fetal origins of adult disease’ has now gained widespread acceptance in the scientific community. In this review, we discuss the evidence for this theory and analyse the patho-physiological mechanisms underlying the relationship between altered fetal growth and coronary heart disease. Finally, the potential relevance of the theory to cardiac surgical practice will be evaluated.

Key Words: Coronary heart disease • Fetal • Undernutrition






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Copyright © 2005 European Association for Cardio-Thoracic Surgery. Published by Elsevier. All rights reserved.