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Eur J Cardiothorac Surg 2005;27:1051-1056
© 2005 Elsevier Science NL

Preoperative statin use and in-hospital outcomes following heart surgery in patients with unstable angina

^a Division of Cardiac Surgery, Dalhousie University, Halifax, NS, Canada
^b Department of Surgery, Dalhousie University, Halifax, NS, Canada
^c Department of Physiology and Biophysics, Dalhousie University, Halifax, NS, Canada

Received 9 October 2004; received in revised form 11 February 2005; accepted 14 February 2005.

^* Corresponding author. Address: QEII HSC, Room 2263, New Infirmary Site, 1796 Summer St., Halifax, NS, Canada B3H 3A7. Tel.: +1 902 473 3808; fax: +1 902 473 4448. (E-mail: imtiaz.ali{at}dal.ca).

Objective: Unstable angina (UA) is characterized by a state of coronary artery vascular inflammation and endothelial dysfunction. Statins mitigate inflammation and endothelial dysfunction and decrease mortality associated with percutaneous interventions for UA. We determined whether preoperative statin use is associated with decreased mortality and morbidity following coronary artery bypass±valve surgery for UA. Methods: Patients with CCS Class IV angina having CABG±valve surgery were identified (n=1706). A logistic regression model determined the association of preoperative statin use with in-hospital mortality (IHM). Propensity score analysis was used to match two sub-groups of patients (GrpI, on statins, n=534; GrpII, not on statins, n=534) on factors known to affect outcomes. Outcomes were IHM, intra-aortic balloon pump (IABP) use, perioperative myocardial infarction (PMI), prolonged (>24h) ventilation (p-vent), stroke, and a composite outcome (comp) defined as any one or more of the above. Results: Of the 1706 patients, 1075 were on statins and 631 were not. Patients on statins were more likely to have isolated CABG, EF>40%, and be on a ß-blocker (P=0.0001); and less likely to have renal failure, MI<7 days, CHF, and undergoing urgent/emergent surgery (P=0.0001). Unadjusted rates of IHM (9 vs. 5%, P=0.001), stroke (4.4 vs. 2.3%, P=0.015), p-vent (28.4 vs. 19%, P=0.0001), and comp (32.5 vs. 22.8%, P=0.0001) were lower in patients receiving statins. After adjustment, statin use was not associated with a reduction in IHM (OR=1.0, 95% CI=0.6–1.5, P=0.85) or comp (OR=1.1, 95% CI=0.8–1.4, P=0.69). No significant differences were found in any of the propensity-adjusted outcomes for GrpI vs. GrpII: IHM (7.1 vs. 6.4%), PMI (2.8 vs. 1.7%), IABP use (3 vs. 3.8%), stroke (3.8 vs. 3.9%), p-vent (26.4 vs. 23.8%), comp (31.5 vs. 27.5%). Conclusions: Preoperative statin use is not associated with a reduction in IHM or major morbidity following CABG±valve surgery in patients with UA.

Key Words: Coronary artery bypass grafting • Statins • Outcomes

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