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Eur J Cardiothorac Surg 2005;28:39-42
© 2005 Elsevier Science NL
a Division of General Thoracic Surgery, Department of Surgery, Keio University, School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582 Japan
b Pathology Department, The Chemo-Sero-Therapeutic Research Institute, Kumamoto, Japan
c Division of Clinicopathology, Keio University Hospital, Tokyo, Japan
Received 4 January 2005; received in revised form 14 February 2005; accepted 15 February 2005.
* Corresponding author. Tel.: +81 3 5363 3806; fax: +81 3 5363 3499. (Email: kawamura{at}sc.itc.keio.ac.jp).
Objective: There is little experimental evidence to show how much positive airway pressure fibrin sealants can actually withstand, and in particular, how this effect changes over time. In the present study, we experimentally evaluated the sealing effect of fibrin glue against alveolar air leakage up to 48h after application. Methods: Beagles were used (n=48). Under thoracotomy, approximately 5x10mm defects (2mm depth) were made on the lung surface. Fibrin glue sealants were applied to this defect in three ways. In rubbing and spray method, fibrinogen was rubbed, followed by spraying of both fibrinogen and thrombin solutions. In double layer method, fibrinogen was dripped, followed by thrombin. Collagen fleece, coated with fibrinogen and thrombin (TachoComb) was also tested. The minimum positive airway pressure which produced air leakage was measured for each sealed defect (seal breaking pressure, cmH2O) at 0, 3, 6, 12, 24, and 48h after application (n=6 at each time point). Results: The seal-breaking pressure increased over time in all of the application methods. At 6h, differences between methods were not significant but three defects in RS reached 70cmH2O, the maximum pressure tested, compared with none in other two methods. At 12h, the seal-breaking pressure was significantly higher in RS compared with the other two methods (rubbing and spray method vs TachoComb; 66±3 vs 47±17, P=0.047, rubbing and spray method vs double layer method; 66±3 vs 42±18, P=0.024). Beyond 24h, sealing pressure reached close to 70cmH2O in all the methods. Conclusions: The results show that the sealing effect of fibrin glue is relatively unstable up to 12h after its application. Rubbing and spray method may help the fibrin seal to reach its full strength faster compared with the other two methods.
Key Words: Fibrin glue • Air leakage • Pulmonary resection • Sealing effect
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