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Eur J Cardiothorac Surg 2005;28:346-348
© 2005 Elsevier Science NL

Case report

Giant aneurysms of the sinuses of Valsalva and aortic regurgitation in a patient with Noonan's syndrome

^a Department of Cardiology, University Hospital of Wales, Heath Park, Cardiff, UK
^b Department of Cardiothoracic Surgery, University Hospital of Wales, Heath Park, Cardiff, UK
^c Department of Vascular Radiology, University Hospital of Wales, Heath Park, Cardiff, UK

Received 10 February 2005; accepted 2 May 2005.

^* Corresponding author. Address: Department of Cardiology, Morriston Hospital, Heol Maes Eglwys, Morriston, Swansea SA6 6NL, USA. Tel.: +44 1792 702222x4477; fax: +44 1792 704140. (Email: richardpurnell{at}aol.com).

Noonan's syndrome is one of the commonest hereditary syndromes with cardiac involvement. We report a rare presentation of this syndrome, associated with giant aneurysms of the left and non-coronary sinuses of Valsalva, resulting in symptomatic aortic valve regurgitation. The patient's clinical investigations and operative management are presented. Histological examination of aortic tissues offers insight into the pathogenesis of these complications.

Key Words: Noonan's syndrome • Giant sinus of Valsalva aneurysms • Aortic regurgitation