| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Eur J Cardiothorac Surg 2005;28:435-442
© 2005 Elsevier Science NL
Original articles |
a Department of Cardiothoracic Surgery, Nagoya University Graduate School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan
b Department of Cardiac Surgery, Aichi Medical University, Aichi, Japan
c Department of Cardiovascular Surgery, Gifu Prefectural Tajimi Hospital, Gifu, Japan
Received 2 March 2005; received in revised form 12 June 2005; accepted 15 June 2005.
* Corresponding author. Tel.: +81 52 744 2375; fax: +81 52 744 2383. (Email: yaraki{at}med.nagoya-u.ac.jp).
Abstract
Objective: It is widely accepted that both valve and cardiac functions are closely correlated. In order to investigate the relationship between the valve and cardiac functions, we developed a model of an isolated working heart with crystalloid perfusate in swine. We investigated the feasibility of this model to evaluate the precise left ventricular function using the pressure–volume relationship and metabolic measurement. Another objective was as a trial for the imaging and analysis of valvular interventions with a high-speed digital camera on this model. Methods: Six isolated working hearts were subjected in the pressure–volume study, and additional three hearts were used in the valve imaging study. Measurement of the pressure–volume relationship was undertaken in situ before the heart was removed, and on the working heart mode during the initial 30min as the baseline, and at every 60min. Lactate levels were measured at every stage in the working heart mode. Mitral valve interventions were performed in three hearts, and valve motions were observed by a high-speed digital camera via the left ventricle. Results: The end-systolic elastance maintained a baseline level (5.17±2.25) until 180min and decreased at 240min (3.97±1.97, NS) and 300min (2.85±1.29, P<0.01) of the working heart mode as compared with baseline. The Tau maintained a constant level until 180min and increased at 240min (62.2±13.3, NS) and 300min (85.5±43.4, P<0.05) as compared with baseline (50.3±13.6). The slope of the end-diastolic pressure–volume relationship gradually increased with no significance until 180min and increased significantly (0.147±0.066, P<0.01 vs 0.067±0.041 at baseline). Lactate increased accumulatively. The total heart energy was reduced from the initial phase of the working heart mode. The valves were well captured by the high-speed digital camera. Conclusions: The systolic and diastolic functions of an isolated heart were preserved at an acceptable level for 180min. The practical reliability of the swine working heart model was demonstrated. This model will be used reliably for the investigation of the interaction of valve and cardiac functions.
Key Words: Animal model • Cardiac function • Heart physiology • Heart valves • Valve imaging
This article has been cited by other articles:
|
|
 |
|
  H. Hasegawa, Y. Araki, A. Usui, J. Yokote, S. Saito, H. Oshima, and Y. Ueda Mitral valve motion after performing an edge-to-edge repair in an isolated swine heart J. Thorac. Cardiovasc. Surg., September 1, 2008; 136(3): 590 - 596. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Saito, Y. Araki, A. Usui, T. Akita, H. Oshima, J. Yokote, and Y. Ueda Mitral valve motion assessed by high-speed video camera in isolated swine heart. Eur. J. Cardiothorac. Surg., October 1, 2006; 30(4): 584 - 591. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
