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Eur J Cardiothorac Surg 2005;28:617-621
© 2005 Elsevier Science NL

Original articles

The relationship of tryptase- and chymase-positive mast cells to angiogenesis in stage I non-small cell lung cancer

^a Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka 569-8686, Japan
^b Department of Thoracic and Cardiovascular Surgery, Osaka Medical College, Takatsuki City, Osaka 569-8686, Japan
^c Department of Pathology, Hoshigaoka Koseinenkin Hospital, 4-8-1, Hoshigaoka, Hirakata City, Osaka 573-8511, Japan
^d Department of Thoracic Surgery, Hoshigaoka Koseinenkin Hospital, 4-8-1, Hoshigaoka, Hirakata City, Osaka 573-8511, Japan

Received 25 March 2005; received in revised form 6 June 2005; accepted 9 June 2005.

^* Corresponding author. Tel.: +81 726 84 7292; fax: +81 726 84 6518. (Email: pha010{at}art.osaka-med.ac.jp).

Abstract

Objective: There are two types of human mast cells, tryptase-positive mast cells (MC_T) and tryptase- and chymase-positive mast cells (MC_TC). Although MC_T have been reported to be related to the generation of angiogenesis, little is known about the involvement of MC_TC in tumor angiogenesis. In this study, to clarify the relationship between MC_TC and lung cancer angiogenesis, we evaluated MC_TC, MC_T, and microvessel counts in normal, border, and central lung cancer regions. Methods: Tumor sections from 32 cases of adenocarcinoma and 13 cases of squamous cell carcinoma were immunostained for chymase to evaluate MC_TC, tryptase to evaluate MC_T, and CD34 to evaluate microvessel counts. Results: Both MC_TC and MC_T counts in the border lung cancer region were significantly higher than in the central region, and the MC_TC and MC_T counts in the central region were significantly higher than those in the normal regions. The microvessel counts in the border region were higher than those in the central region. The ratio of MC_TC to MC_T in the border region, but not in the central region, was significantly higher than that in the normal region. In the border region, significant correlations not only between MC_T and microvessel count, but also between MC_TC and microvessel count were observed. In the central region, a significant correlation between MC_TC and the microvessel count was observed, but there was no significant correlation between MC_T and the microvessel count. Conclusions: These findings suggest that MC_TC may be involved in the pathogenesis of angiogenesis in lung cancer.

Key Words: Angiogenesis • Lung cancer • Chymase • Mast cells • Human

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