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European Journal of Cardio-Thoracic Surgery, Vol 3, 87-88, Copyright © 1989 by European Association for Cardio-thoracic Surgery

ARTICLES

In vitro thrombolysis of thrombosed valve prostheses: therapeutic considerations of left-sided thrombotic lesions

HY Karagoz, KM Babacan, YI Zorlutuna, O Tasdemir, C Yakut and K Bayazit
Department of Cardiovascular Surgery, Higher Specialization Hospital of Turkey, Ankara.

Six thrombosed Bjork-Shiley mitral valve prostheses which had been removed in emergency reoperations between November 1985 and December 1986 underwent in vitro thrombolysis with urokinase. After a mean period of 14 +/- 3 h of in vitro fibrinolysis, lysis of thrombus was observed, but large fragments of organized thrombus were released into the medium, suggesting that thrombolytic therapy should not be used for thrombotic occlusions on the left side of the heart, as the risk of systemic embolization is high.




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Copyright © 1989 European Association for Cardio-Thoracic Surgery. Published by Elsevier. All rights reserved.