HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Aravot, D. J. Articles by Yacoub, M. H. Search for Related Content PubMed PubMed Citation Articles by Aravot, D. J. Articles by Yacoub, M. H.

European Journal of Cardio-Thoracic Surgery, Vol 3, 521-524, Copyright © 1989 by European Association for Cardio-thoracic Surgery

ARTICLES

Primary cardiac tumours--is there a place for cardiac transplantation?

DJ Aravot, NR Banner, B Madden, S Aranki, A Khaghani, M Fitzgerald, R Radley- Smith and MH Yacoub
Cardiac Surgical Unit, Harefield Hospital, Middlesex, UK.

Between 1979 and 1985, seven patients (five children and two adults) were treated for primary cardiac tumours other than benign atrial myxomas. There were five malignant neoplasms (two non-classifiable sarcomas, one haemangiosarcoma, one histiocytoma and one neurofibrosarcoma) and two benign tumours (fibromas). Echocardiography, cardiac catheterisation, computed tomography and magnetic resonance imaging provided diagnostic confirmation. The two patients with fibroma are alive and well 4 and 5 years after radical resection of the tumours from the interventricular septum. The patient with a neurofibrosarcoma underwent orthotopic cardiac transplantation and is well 5.5 years postoperatively with no evidence of residual disease or recurrence. One patient died awaiting a donor heart for transplantation. Another patient who was a candidate for heart and lung transplantation was found to have an unresectable tumour at the time of operation. One patient with sarcoma who underwent a successful emergency partial resection for relief of cardiac tamponade died 18 months later from widespread metastases. The seventh patient was inoperable due to multiple secondaries. It is concluded that radical resection of large, benign, cardiac tumours can give good results and that early cardiac transplantation probably offers the only hope for patients with malignant tumours of the heart.

This article has been cited by other articles:

				B. Davies, G. Oppido, and C. P. Brizard Surgical management of symptomatic cardiac fibromas in children J. Thorac. Cardiovasc. Surg., January 1, 2007; 133(1): 254 - 255. [Full Text] [PDF]

				S. M. Talbot, R. N. Taub, M. L. Keohan, N. Edwards, M. E. Galantowicz, and L. L. Schulman Combined heart and lung transplantation for unresectable primary cardiac sarcoma J. Thorac. Cardiovasc. Surg., December 1, 2002; 124(6): 1145 - 1148. [Abstract] [Full Text]

				J.-C. Chachques, P. G. Argyriadis, C. Latremouille, N. D'Attellis, P. Fornes, P. Bruneval, J.-P. Couetil, and A. F. Carpentier Cardiomyoplasty: Ventricular reconstruction after tumor resection J. Thorac. Cardiovasc. Surg., May 1, 2002; 123(5): 889 - 894. [Abstract] [Full Text] [PDF]

				D. Grandmougin, G. Fayad, C. Decoene, A. Pol, and H. Warembourg Total orthotopic heart transplantation for primary cardiac rhabdomyosarcoma: factors influencing long-term survival Ann. Thorac. Surg., May 1, 2001; 71(5): 1438 - 1441. [Abstract] [Full Text] [PDF]

				T. J. Takach, G. J. Reul, D. A. Ott, and D. A. Cooley Primary Cardiac Tumors in Infants and Children: Immediate and Long-Term Operative Results Ann. Thorac. Surg., August 1, 1996; 62(2): 559 - 564. [Abstract] [Full Text]

				M. R. Costanzo, S. Augustine, R. Bourge, M. Bristow, J. B. O'Connell, D. Driscoll, and E. Rose Selection and Treatment of Candidates for Heart Transplantation : A Statement for Health Professionals From the Committee on Heart Failure and Cardiac Transplantation of the Council on Clinical Cardiology, American Heart Association Circulation, December 15, 1995; 92(12): 3593 - 3612. [Abstract] [Full Text]

				D. J. Goldstein, M. C. Oz, and R. E. Michler Radical excisional therapy and total cardiac transplantation for recurrent atrial myxoma. Ann. Thorac. Surg., October 1, 1995; 60(4): 1105 - 1107. [Abstract] [Full Text]

				J. Bachet, C. Banfi, L. Martinelli, D. Brodaty, D. Guilmet, T. X. Aufiero, and W. E. Pae Jr Heart transplantation and primary cardiac tumors. Ann. Thorac. Surg., January 1, 1995; 59(1): 262 - 263. [Full Text]