HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Darracott-Cankovic, S. Articles by English, T. A. Search for Related Content PubMed PubMed Citation Articles by Darracott-Cankovic, S. Articles by English, T. A.

European Journal of Cardio-Thoracic Surgery, Vol 3, 525-532, Copyright © 1989 by European Association for Cardio-thoracic Surgery

ARTICLES

Effect of donor heart damage on survival after transplantation

S Darracott-Cankovic, PG Stovin, D Wheeldon, J Wallwork, F Wells and TA English
Cardiothoracic Research Unit, Rayne Institute, St. Thomas Hospital, London, UK.

Evaluation of the functional condition of the heart prior to its removal from the donor or after transport to the recipient is difficult. Biopsies of the myocardium allow serial assessments to be made throughout this period, but suffer from the disadvantage that the average analysis of biopsies has only a tenuous connection with physiological function. Quantitative birefringence measurements (QBM), on the other hand, assess the ability of myocardial fibres to respond to ATP and calcium and have been shown to correlate well with measurements of cardiac function (P less than 0.001). A prospective study of myocardial biopsies before excision, after transport and again after transplantation, using quantitative birefringence measurement of biopsies of the heart has recently been completed. These studies have shown evidence of impaired myocardial function in 73 (43%) of 172 donor hearts studied prior to excision, with a further 27% showing significant deterioration during storage and transport to the recipient. Biopsy assessments therefore indicated that at the moment of implantation, only 30% of the donor hearts were normal. Functional assessment of the biopsies by QBM correlated with early clinical outcome of transplantation (P less than 0.001). Longer term follow-up of the recipients (up to 5 years) has shown that the mortality of recipients of hearts with impaired function before transplantation is significantly increased (44% of 120) compared with that of recipients of undamaged hearts (6% of 52, P less than 0.001).

This article has been cited by other articles:

				M. D. Diodato, N. R. Shah, S. M. Prasad, S. L. Gaynor, J. S. Lawton, and R. J. Damiano Jr Donor heart preservation with pinacidil: the role of the mitochondrial KATP channel Ann. Thorac. Surg., August 1, 2004; 78(2): 620 - 627. [Abstract] [Full Text] [PDF]

				S. C. Stoica, D. K. Satchithananda, C. Atkinson, P. A. White, A. N. Redington, M. Goddard, T. Kealey, and S. R. Large The energy metabolism in the right and left ventricles of human donor hearts across transplantation Eur. J. Cardiothorac. Surg., April 1, 2003; 23(4): 503 - 512. [Abstract] [Full Text] [PDF]

				E. M. Hoenicke, X. Sun, R. G. Strange Jr, and R. J. Damiano Jr Donor heart preservation with a novel hyperpolarizing solution: Superior protection compared with University of Wisconsin solution J. Thorac. Cardiovasc. Surg., October 1, 2000; 120(4): 746 - 754. [Abstract] [Full Text] [PDF]

				E. J. Birks, V. J. Owen, P. B. J. Burton, A. E. Bishop, N. R. Banner, A. Khaghani, J. M. Polak, and M. H. Yacoub Tumor Necrosis Factor-{alpha} Is Expressed in Donor Heart and Predicts Right Ventricular Failure After Human Heart Transplantation Circulation, July 18, 2000; 102(3): 326 - 331. [Abstract] [Full Text] [PDF]

				C. M.R. Satur, D. Doyle, S. Darracott-Cankovic, W. Martin, and D. J. Wheatley Can technetium 99m pyrophosphate be used to quantify myocardial injury in donor hearts? Ann. Thorac. Surg., December 1, 1999; 68(6): 2225 - 2230. [Abstract] [Full Text] [PDF]

				P. Vijay, V. A. Scavo, R. J. Morelock, T. G. Sharp, and J. W. Brown Donor cardiac troponin T: a marker to predict heart transplant rejection Ann. Thorac. Surg., December 1, 1998; 66(6): 1934 - 1938. [Abstract] [Full Text] [PDF]

				J. Caspi, J. G. Coles, L. N. Benson, and G. J. Wilson Brain Damage and Myocardial Dysfunction: Protective Effects of Magnesium in the Newborn Pig Ann. Thorac. Surg., June 1, 1998; 65(6): 1730 - 1736. [Abstract] [Full Text] [PDF]

				H. B. Bittner, E. P. Chen, C. A. Milano, S. W.H. Kendall, R. B. Jennings, D. C. Sabiston Jr, and P. Van Trigt Myocardial ß-Adrenergic Receptor Function and High-Energy Phosphates in Brain Death– Related Cardiac Dysfunction Circulation, November 1, 1995; 92(9): 472 - 478. [Abstract] [Full Text]

				B. Riou, S. Dreux, S. Roche, M. Arthaud, J.-P. Goarin, P. Leger, M. Saada, and P. Viars Circulating Cardiac Troponin T in Potential Heart Transplant Donors Circulation, August 1, 1995; 92(3): 409 - 414. [Abstract] [Full Text]

				H. B. Bittner, S. W. H. Kendall, E. P. Chen, R. D. Davis, and P. Van Trigt III Myocardial Performance After Graft Preservation and Subsequent Cardiac Transplantation From Brain-Dead Donors Ann. Thorac. Surg., July 1, 1995; 60(1): 47 - 54. [Abstract] [Full Text]