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Eur J Cardiothorac Surg 2006;30:164-167
© 2006 Elsevier Science NL

Sampling or node dissection for intraoperative staging of lung cancer: a multicentric cross-sectional study

^a Service de Chirurgie Thoracique, Hôpital Civil, 67091 Strasbourg, France
^b Cardiothoracic Center, 140 Ulitsa Rossiskaia, 350086 Krasnodar, Russian Federation
^c Service de Chirurgie Thoracique, Hôpital Européen Georges Pompidou, 20 rue Louis Leblanc, 75908 Paris, France

Received 27 February 2006; received in revised form 30 March 2006; accepted 6 April 2006.

^_* Corresponding author. Address: Service de Chirurgie Thoracique, Hôpital Civil, 67091 Strasbourg, France. Tel.: +33 3 88 11 62 02; fax: +33 3 88 11 60 77. (Email: Gilbert.Massard{at}chru-strasbourg.fr).

Objective: This study compares accuracy of sampling versus formal node dissection in patients with primary lung cancer. Patients and methods: During a 4-month period, 208 consecutive patients (172 men, 36 women) without bulky disease underwent resection for primary lung cancer in three centers. The surgeon first sampled the main lymph node stations, and subsequently performed a radical mediastinal dissection. Endpoints were accuracy of prediction for stage N2 and radicality of node sampling compared to dissection. Results: Resection consisted of 1 segmentectomy, 142 standard lobectomies, 6 bilobectomies, 14 sleeve-lobectomies, and 45 pneumonectomies. There were 108 squamous cell carcinomas, 621 adenocarcinomas, 18 bronchoalveolar carcinomas, 8 large cell carcinomas, 4 adenosquamous carcinomas and 8 neuroendocrine carcinomas. Primary tumor was stage T1 in 49 patients, T2 in 110, T3 in 43, and T4 in 6. Lymph node status (dissection) was N0 in 113, N1 in 35, and N2 in 60 patients. N2 disease concerned a single node in 16, a single node station in 19, and multiple levels in 25. Both N1 and N2 nodes were diseased in 36 patients. Sampling adequately recognized N2 disease in 31 patients (52%). Multiple level N2 was accurately identified in 10 patients (40%). Resection based on sampling would have been incomplete in 53 patients (88%). Conclusion: Radical mediastinal dissection is a mandatory adjunct to resection for lung cancer with curative attempt.

Key Words: Surgery • Lung cancer • Lymph node dissection

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