EJCTS Click here for details of sales representative
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gurbanov, E.
Right arrow Articles by Shiliang, X.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gurbanov, E.
Right arrow Articles by Shiliang, X.
Related Collections
Right arrow Congenital - cyanotic
Right arrow Great vessels
Right arrow Valve disease

Eur J Cardiothorac Surg 2006;30:499-507
© 2006 Elsevier Science NL

Review

The key role of apoptosis in the pathogenesis and treatment of pulmonary hypertension

Emin Gurbanova,*, Xiao Shiliangb,1

a Huazhong University of Science and Technology, Tongji Medical College, Union Hospital, Department of Cardiovascular Surgery, Wuhan 430030, PR China
b Huazhong University of Science and Technology, Union Hospital, Department of Cardiovascular Surgery, Wuhan 430030, PR China

Received 8 March 2006; received in revised form 8 May 2006; accepted 15 May 2006.

* Corresponding author. Tel.: +86 83691185. (Email: emin_cn{at}yahoo.com; shi_liangxiao{at}yahoo.com).

In recent years, the process of the programmed cell death has gained much interest because it has important pathophysiological consequences contributing to the deletion of unwanted cells in the vessel wall, loss of pulmonary smooth muscle cells and therefore in reversing the pulmonary pressure. For the reason that most patients with pulmonary hypertension present with limited reversibility with vasodilators, antiremodeling approach for treatment appears to be feasible. Induction or enhancement of vascular smooth muscle cells apoptosis may be targeted to develop novel therapeutic approaches for pulmonary vascular remodeling in patients with pulmonary hypertension.

This review summarizes the current mechanisms, investigate the roles and provide novel insights into the potential therapeutic value of apoptosis in the pulmonary artery remodeling of pulmonary hypertension.

Key Words: Apoptosis • Remodeling • Pulmonary hypertension • Muscle • Smooth






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2006 European Association for Cardio-Thoracic Surgery. Published by Elsevier. All rights reserved.