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Eur J Cardiothorac Surg 2006;30:782-786
© 2006 Elsevier Science NL

Reviews

Tissue-engineered trachea: History, problems and the future

^a Clinic of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland
^b Division of Oncology, University Hospital Zurich, Zurich, Switzerland
^c Division of Surgical Research and Clinic for Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland

Received 15 June 2006; received in revised form 21 August 2006; accepted 24 August 2006.

^_* Corresponding author. Address: Clinic of Thoracic Surgery, University Hospital Zurich, Raemistrasse 100, CH-8091 Zurich, Switzerland. Tel.: +41 1 255 34 16; fax: +41 1 255 88 05. (Email: tqiang{at}hotmail.com).

This review tries to summarize the efforts over the past 20 years to construct a tissue-engineered trachea. After illustrating the main technical bottlenecks faced nowadays, we discuss what might be the solutions to these bottlenecks. You may find out why the focus in this research field shifts dramatically from the construction of a tubular cartilage tissue to reepithelialization and revascularization of the prosthesis. In the end we propose a novel concept of ‘in vivo bioreactor’, defined as the design of a perfusion system inside the scaffold, and explain its potential application in the construction of a tissue-engineered trachea.

Key Words: Tissue engineering • Tracheal surgery • Revascularization • Reepithelialization

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