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Eur J Cardiothorac Surg 2007;31:438-443. doi:10.1016/j.ejcts.2006.11.057
Copyright © 2007, European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved

Optimal temporal delivery of bone marrow mesenchymal stem cells in rats with myocardial infarction

^a Department of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, 3 East Qing Chun Road, Hangzhou 310016, China
^b Department of Cardiology, Second Affiliated Hospital, College of Medicine, Zhejiang University, 88 Jie Fang Road, Hangzhou 310009, China
^c Department of Cardiology, First Affiliated Hospital, Zhejiang Chinese Medical University, 54 You Dian Road, Hangzhou 310006, China

Received 28 September 2006; received in revised form 21 November 2006; accepted 24 November 2006.

^_* Corresponding author. Tel.: +86 571 87784677. (Email: wang_jian_an{at}tom.com).

Objective: This study was designed to determine the optimal time point for bone marrow mesenchymal stem cell (MSC) transplantation after myocardial infarction (MI). Methods: MSCs from donor rats were labeled with DAPI before transplantation. The animals underwent MI by ligation of left anterior descending coronary artery, and received intramyocardial injection of MSCs at 1 h, 1 week and 2 weeks after MI, respectively. Sham-operated and MI control groups received equal volume phosphate buffered saline. Cardiac function, histological analysis and immunoblot for troponin T were performed 4 weeks after cell transplantation. Results: MSC transplantation attenuated left ventricular chamber dilation, reduced infarct size, and improved cardiac function in rats after MI. The greatest benefit was achieved in rats that received cells 1 week after MI, engrafted MSC survival, angiogenesis and functional cardiomyocytes in the injured hearts were more abundant in these rats than that in other transplantation groups. Conclusions: The optimal functional benefit of MSC transplantation was observed in 1-week transplantation group. At this time point scar formation has not occurred and the inflammation is reduced, which should facilitate integration of transplanted cells and functional recovery.

Key Words: Cell transplantation • Time point • Myocardial infarction

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