HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Olivier Ghez Victor T. Tsang Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ghez, O. Articles by De Leval, M. Search for Related Content PubMed PubMed Citation Articles by Ghez, O. Articles by De Leval, M. Related Collections Congenital - acyanotic Valve disease

Eur J Cardiothorac Surg 2007;31:654-658. doi:10.1016/j.ejcts.2006.12.031
Copyright © 2007, European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved

Right ventricular outflow tract reconstruction for pulmonary regurgitation after repair of tetralogy of Fallot.

Preliminary results

Great Ormond Street Hospital for Children, The Heart Hospital, Institute of Child Health, London, United Kingdom

Received 12 September 2006; received in revised form 25 November 2006; accepted 22 December 2006.

^_* Corresponding author. Address: Cardiac Unit, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, WC1N 3JH London, United Kingdom. Tel.: +44 20 74059200x5298; fax: +44 20 74301281. (Email: tsangv{at}gosh.nhs.uk).

Background: Pulmonary regurgitation after tetralogy of Fallot (ToF) repair is associated with right ventricular dilatation, failure and arrhythmia. Timing and technique for re-intervention remain controversial. Methods: Our recent approach is to reconstruct the dilated right ventricle outflow tract (RVOT) as a fibro-muscular sleeve to support a pulmonary homograft valve conduit in orthotopic position. Indication is based on clinical and magnetic resonance (MR) criteria. We reviewed all patients who underwent RVOT reconstruction between January 2004 and February 2005. There were seven children (mean age 14 ± 2 years) operated 13 ± 2 years after ToF repair, and 12 adults (mean age 30 ± 15 years) operated 23 ± 10 years after ToF repair. Exercise testing and MR evaluation prior to surgery and at 1 year postoperative follow-up were compared. Results: There was no operative mortality. At 1 year, pulmonary regurgitation was mild or less in 16/19 patients. Right ventricular (RV) end-diastolic (158 ± 51 to 103 ± 36 ml/m², p < 0.001) and end-systolic volumes (85 ± 42 to 49 ± 24 ml/m², p = 0.001) fell significantly. Importantly, effective RV stroke volume (43 ± 10 to 48 ± 7 ml/m², p = 0.019) and left ventricular (LV) stroke volume (43 ± 7 to 47 ± 7 ml/m², p = 0.009) increased significantly. The mean RV/LV end-diastolic volume ratio fell markedly in both children and adults (2.22 ± 0.62 to 1.38 ± 0.52). However, no improvement in maximal VO₂ on exercise was noted in either group. Conclusions: RVOT reconstruction restored valve function, improved RV dimensions and left and right stroke volumes. Maximal exercise capacity did not improve in either children or adults.

Key Words: Tetralogy of Fallot • Homograft • Pulmonary regurgitation

This article has been cited by other articles:

				A. Frigiola, V. Tsang, C. Bull, L. Coats, S. Khambadkone, G. Derrick, B. Mist, F. Walker, C. van Doorn, P. Bonhoeffer, et al. Biventricular Response After Pulmonary Valve Replacement for Right Ventricular Outflow Tract Dysfunction: Is Age a Predictor of Outcome? Circulation, September 30, 2008; 118(14_suppl_1): S182 - S190. [Abstract] [Full Text] [PDF]

				A. Frigiola, V. Tsang, J. Nordmeyer, P. Lurz, C. van Doorn, A. M. Taylor, P. Bonhoeffer, and M. de Leval Current approaches to pulmonary regurgitation Eur. J. Cardiothorac. Surg., September 1, 2008; 34(3): 576 - 581. [Abstract] [Full Text] [PDF]

				P. R. Vouhe Editorial comment Eur. J. Cardiothorac. Surg., September 1, 2008; 34(3): 581 - 582. [Full Text] [PDF]

				P. Lurz, L. Coats, S. Khambadkone, J. Nordmeyer, Y. Boudjemline, S. Schievano, V. Muthurangu, T. Y. Lee, G. Parenzan, G. Derrick, et al. Percutaneous Pulmonary Valve Implantation: Impact of Evolving Technology and Learning Curve on Clinical Outcome Circulation, April 15, 2008; 117(15): 1964 - 1972. [Abstract] [Full Text] [PDF]

				M. Kostolny, V. Tsang, J. Nordmeyer, C. Van Doorn, A. Frigiola, S. Khambadkone, M. R. de Leval, and P. Bonhoeffer Rescue surgery following percutaneous pulmonary valve implantation Eur. J. Cardiothorac. Surg., April 1, 2008; 33(4): 607 - 612. [Abstract] [Full Text] [PDF]

				S. Dittrich, M. Gloeckler, R. Arnold, K. Sarai, M. Siepe, F. Beyersdorf, and C. Schlensak Hybrid Pulmonary Valve Implantation: Injection of a Self-Expanding Tissue Valve Through the Main Pulmonary Artery Ann. Thorac. Surg., February 1, 2008; 85(2): 632 - 634. [Abstract] [Full Text] [PDF]