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Eur J Cardiothorac Surg 2007;31:860-865. doi:10.1016/j.ejcts.2007.02.006
Copyright © 2007, European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved

Long-term follow-up after mitral valve replacement in childhood: poor event-free survival in the young child

Cardiothoracic Unit, Great Ormond Street Hospital for Children National Health Service Trust, London, United Kingdom

Received 29 November 2006; received in revised form 22 January 2007; accepted 2 February 2007.

^_* Corresponding author. Address: Great Ormond Street Hospital for Children National Health Service Trust, London WC1N 3JH, United Kingdom. Tel.: +44 207 4059200x5178; fax: +44 207 7626752. (Email: vandoc{at}gosh.nhs.uk).

Objective: In children, mechanical mitral valve replacement may be the only option if the failing mitral valve cannot be repaired. Mandatory anticoagulation and the fixed size prosthesis are of concern in the growing child, but long-term follow-up results are lacking. Methods: Single centre, extended retrospective study of 54 patients who underwent first mitral valve replacement between June 1982 and December 1997. Median age at operation was 3.0 years (range 2 days–18.1 years), 21 patients were 2.0-year-old. Mitral valve replacement was performed for congenital (43 patients) or acquired (11 patients) heart disease. Median follow-up for operative survivors was 9.2 years, with follow-up > 15 years (maximum 22 years) in nine patients. Results: Thirty-day mortality was 42% in patients 2-year-old, and 6% in older patients. There were 10 late deaths. Estimated survival at 10 and 15 years follow-up was 33% ± 19% and 33 ± 27% in patients 2-year-old, and 81% ± 8% and 75% ± 16% in older patients, respectively. High operative mortality in the younger age group was the most important contributor to poor long-term survival. Fifteen patients underwent redo-mitral valve replacement with one operative death. A larger valve was always implanted. Freedom from redo-mitral valve replacement at 10 and 15 years was 25% ± 22% and 0% in patients with prostheses < 23 mm, and 83% ± 13% and 83% ± 27% in patients with larger prostheses. Significant bleeding events occurred in eight patients and were often associated with operative interventions. Estimated freedom from bleeding was 75.7% ± 9% and 70.6% ± 16% at 10 and 15 years, respectively. Thromboembolism and endocarditis were rare. There was no structural valve failure. Estimated freedom from all adverse events at 10 years follow-up was 17% ± 13%. Conclusions: At 10 years follow-up after mechanical mitral valve replacement, most children had suffered an adverse event. At 15 years, all children with a prosthesis < 23 mm had outgrown their valve, but redo-mitral valve replacement with a larger size prosthesis was always possible, and carried low operative risk. Long-term anticoagulation was well tolerated. In children every effort should be made to preserve the native valve.

Key Words: Mitral valve replacement • Child • Long-term follow-up

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